Related ArticlesSolution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.
Molecules. 2017 Aug 31;22(9):
Authors: Kim DH, Kang SM, Lee BJ
Abstract
Tuberculosis is an infectious disease caused by Mycobacteriumtuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health. Because of the development of drug-resistant tuberculosis, there is an urgent need for novel antibiotics to treat these drug-resistant bacteria. In light of the clinical importance of M. tuberculosis, 2067 structures of M. tuberculsosis proteins have been determined. Among them, 52 structures have been solved and studied using solution nuclear magnetic resonance (NMR). The functional details based on structural analysis of M. tuberculosis using NMR can provide essential biochemical data for the development of novel antibiotic drugs. In this review, we introduce diverse structural and biochemical studies on M. tuberculosis proteins determined using NMR spectroscopy.
The PE_PGRS Proteins of Mycobacterium tuberculosis Are Ca2+ Binding Mediators of Host–Pathogen Interaction
The PE_PGRS Proteins of Mycobacterium tuberculosis Are Ca2+ Binding Mediators of Host–Pathogen Interaction
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.6b00289/20160811/images/medium/bi-2016-00289f_0009.gif
Biochemistry
DOI: 10.1021/acs.biochem.6b00289
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08-11-2016 07:03 PM
[NMR paper] Solution NMR studies on Helicobacter pylori proteins for antibiotic target discovery.
Solution NMR studies on Helicobacter pylori proteins for antibiotic target discovery.
Related Articles Solution NMR studies on Helicobacter pylori proteins for antibiotic target discovery.
Expert Opin Drug Discov. 2016 May 23;
Authors: Lee KY, Lee BJ
Abstract
INTRODUCTION: Helicobacter pylori (H. pylori) is a well-known widespread pathogenic bacterium that survives in the extremely acidic conditions of the human gastric mucosa. The global prevalence of H. pylori-resistant antibiotics has become an emerging issue in the 21st...
[NMR paper] NMR Study on Small Proteins from Helicobacter pylori for Antibiotic Target Discovery: A Review.
NMR Study on Small Proteins from Helicobacter pylori for Antibiotic Target Discovery: A Review.
NMR Study on Small Proteins from Helicobacter pylori for Antibiotic Target Discovery: A Review.
Molecules. 2013;18(11):13410-24
Authors: Kang SJ, Kim DH, Lee BJ
Abstract
Due to the widespread and increasing appearance of antibiotic resistance, a new strategy is needed for developing novel antibiotics. Especially, there are no specific antibiotics for Helicobacter pylori (H. pylori). H. pylori are bacteria that live in the stomach and are...
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11-02-2013 10:04 AM
Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis.
Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis.
Solution-state NMR structure and biophysical characterization of zinc-substituted rubredoxin B (Rv3250c) from Mycobacterium tuberculosis.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1148-53
Authors: Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ
Abstract
Owing to the evolution of multi-drug-resistant and extremely drug-resistant Mycobacterium tuberculosis strains,...
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09-10-2011 06:51 PM
[NMR paper] NMR assignment of protein Rv1980c from Mycobacterium tuberculosis.
NMR assignment of protein Rv1980c from Mycobacterium tuberculosis.
Related Articles NMR assignment of protein Rv1980c from Mycobacterium tuberculosis.
J Biomol NMR. 2005 Sep;33(1):73
Authors: Danahy JM, Potter BM, Geisbrecht BV, Laity JH
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Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Scr
Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Screening of Antigen 85C.
Related Articles Novel Small Molecule Inhibitors of MDR Mycobacterium tuberculosis by NMR Fragment Screening of Antigen 85C.
J Med Chem. 2010 Nov 12;
Authors: Scheich C, Puetter V, Schade M
Protein target-based discovery of novel antibiotics has been largely unsuccessful despite rich genome information. Particularly in need are new antibiotics for tuberculosis, which kills 1.6 million people annually and shows a rapid increase in...
Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery.
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