Solution NMR backbone resonance assignment of the full-length resistance-related calcium-binding protein Sorcin
 

Solution NMR backbone resonance assignment of the full-length resistance-related calcium-binding protein Sorcin

Sorcin is a penta-EF hand calcium-binding protein that confers multidrug resistance in cancer cells. It regulates cellular Ca^(2+) homeostasis by interacting with calcium channels such as Ryanodine receptor 2 and Sarcoplasmic/endoplasmic reticulum Ca^(2+)-ATPase in a calcium-dependent manner. The crystal structure of the Sorcin has been determined in both calcium-free and calcium-bound states to understand calcium-binding induced conformational change. However, due to its flexibility, most of...

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