Publication date: Available online 30 March 2015 Source:Progress in Nuclear Magnetic Resonance Spectroscopy
Author(s): Adrianus J. Bakermans , Desiree Abdurrachim , Rik P.M. Moonen , Abdallah G. Motaal , Jeanine J. Prompers , Gustav J. Strijkers , Katrien Vandoorne , Klaas Nicolay
The use of MR imaging and spectroscopy for studying cardiovascular disease processes in small animals has increased tremendously over the past decade. This is the result of the remarkable advances in MR technologies and the increased availability of genetically modified mice. MR techniques provide a window on the entire timeline of cardiovascular disease development, ranging from subtle early changes in myocardial metabolism that often mark disease onset to severe myocardial dysfunction associated with end-stage heart failure. MR imaging and spectroscopy techniques play an important role in basic cardiovascular research and in cardiovascular disease diagnosis and therapy follow-up. This is due to the broad range of functional, structural and metabolic parameters that can be quantified by MR under in vivo conditions non-invasively. This review describes the spectrum of MR techniques that are employed in small animal cardiovascular disease research and how the technological challenges resulting from the small dimensions of heart and blood vessels as well as high heart and respiratory rates, particularly in mice, are tackled. Graphical abstract
Highlights
Multi-parametric magnetic resonance imaging and spectroscopy are powerful tools for measuring the anatomy, structure, function and metabolism of the cardiovascular system in small animals. The use of targeted contrast agents in addition provides handles for the detection of molecular markers. This review describes the state-of-the-art of small animal MRI and MRS for studying cardiovascular disease processes and highlights recent advances, covering the entire timeline from early changes at the molecular level to gross impairments in function and anatomy.
Real-time cardiac metabolism assessed with hyperpolarized [1-13C]acetate in a large-animal model
From The DNP-NMR Blog:
Real-time cardiac metabolism assessed with hyperpolarized acetate in a large-animal model
Flori, A., et al., Real-time cardiac metabolism assessed with hyperpolarized acetate in a large-animal model. Contrast Media & Molecular Imaging, 2014: p. n/a-n/a.
http://dx.doi.org/10.1002/cmmi.1618
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Cardiovascular Applications of Hyperpolarized MRI
Tyler, D., Cardiovascular Applications of Hyperpolarized MRI. Curr Cardiovasc Imaging Rep, 2011. 4(2): p. 108-115.
http://dx.doi.org/10.1007/s12410-011-9066-8
Many applications of MRI are limited by an inherently low sensitivity. Previous attempts to overcome this insensitivity have focused on the use of MRI systems with stronger magnetic fields. However, the gains that can be achieved in this way are relatively small and increasing the magnetic field invariably leads to greater technical...
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Mol Biol (Mosk) (2010). Volume: 44, Issue: 6. Pages: 1075-1085. A N Istrate, A B Mantsyzov, S A Kozin, V I Pol'shakov et al.
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The Ca(2+)-dependent carbohydrate-recognition domain (CRD) of rat serum mannose-binding protein has been subjected to site-directed mutagenesis to determine the...
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[NMR paper] Binding of sugar ligands to Ca(2+)-dependent animal lectins. I. Analysis of mannose b
Binding of sugar ligands to Ca(2+)-dependent animal lectins. I. Analysis of mannose binding by site-directed mutagenesis and NMR.
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J Biol Chem. 1994 Jun 3;269(22):15505-11
Authors: Iobst ST, Wormald MR, Weis WI, Dwek RA, Drickamer K
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Small animal cardiovascular MR imaging and spectroscopy
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