Related ArticlesSerum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy.
Mol Biosyst. 2014 Dec;10(12):3170-8
Authors: Yang Y, Liu Y, Zheng L, Wu T, Li J, Zhang Q, Li X, Yuan F, Wang L, Guo J
Abstract
Atherosclerosis is a multifactorial and progressive disease commonly correlated with a high fat diet. The aim of this study was to identify potential biomarkers for the early diagnosis and monitoring of the progression of atherogenesis in apoE(-/-) mice using (1)H NMR-based metabonomics. The apoE(-/-) mice were split into four groups according to the duration of high fat feeding (0 w, 2 w, 4 w and 8 w), and each group possessed different pathological characteristics. Serum (1)H NMR-based metabonomics selectively captured the metabotypes that correlated with the degree of atherosclerosis, showing a time-dependent progression from the physiological to pathophysiological status. It was noted that changes in HDL, choline, taurine, glycine and glucose may be regarded as specific biomarkers of the early stage of atherosclerosis. With the progression of atherosclerosis, disorders in the metabolism of amino acids such as valine, alanine and methionine appeared when large atherosclerotic plaques existed. Multiple biochemical disorders involving lipid metabolism, energy and fatty acid metabolism were observed in the progression of atherosclerosis in apoE(-/-) mice. This study demonstrated that (1)H NMR-based metabonomics can provide biochemical information about the progression of atherogenesis and offer a non-invasive means to discover potential biomarkers for the onset and development of atherosclerosis.
[NMR paper] NMR-based lipidomic analysis of blood lipoproteins differentiates the progression of coronary heart disease.
NMR-based lipidomic analysis of blood lipoproteins differentiates the progression of coronary heart disease.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles NMR-based lipidomic analysis of blood lipoproteins differentiates the progression of coronary heart disease.
J Proteome Res. 2014 May 2;13(5):2585-98
Authors: Kostara CE, Papathanasiou A, Psychogios N, Cung MT, Elisaf MS, Goudevenos J, Bairaktari ET
Abstract
Abnormal lipid composition and...
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[NMR paper] Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Mol Biosyst. 2014 Jan 21;
Authors: Diao C, Zhao L, Guan M, Zheng Y, Chen M, Yang Y, Lin L, Chen W, Gao H
Abstract
Diabetes mellitus is a typical heterogeneous metabolic disorder characterized by abnormal...
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01-23-2014 03:58 PM
[NMR paper] Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy...
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[NMR paper] Fecal and urinary NMR-based metabolomics unveil an aging signature in mice.
Fecal and urinary NMR-based metabolomics unveil an aging signature in mice.
Related Articles Fecal and urinary NMR-based metabolomics unveil an aging signature in mice.
Exp Gerontol. 2013 Oct 29;
Authors: Calvani R, Brasili E, Pratic̣ G, Capuani G, Tomassini A, Marini F, Sciubba F, Finamore A, Roselli M, Marzetti E, Miccheli A
Abstract
BACKGROUND: Aging is characterized by derangements in multiple metabolic pathways that progressively constrict the homeostatic reserve (homeostenosis). The signature of metabolic alterations that accompany...
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11-05-2013 06:53 PM
[NMR paper] 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
Chem Biol Interact. 2013 May 25;203(3):588-96
Authors: Wang HP, Liang YJ, Sun YJ, Chen JX,...
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[NMR paper] Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Int J Endocrinol Metab. 2012;10(3):548-552
Authors: Rezaei-Tavirani M, Fathi F, Darvizeh F, Zali MR, Rostami Nejad M, Rostami K, Tafazzoli M, Arefi Oskouie A, Mortazavi-Tabatabaei SA
Abstract
BACKGROUND: Celiac disease (CD) is a disorder associated with body reaction to gluten. After the gluten intake, an immune reaction against the protein occurs and damages villi of small...
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07-12-2013 06:01 PM
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
J Nutr Biochem. 2011 Mar 21;
Authors: He Q, Ren P, Kong X, Wu Y, Wu G, Li P, Hao F, Tang H, Blachier F, Yin Y
Childhood obesity has become a prevalent risk to health of children and teenagers. To develop biomarkers in serum for altered lipid metabolism, genetically obese (Ningxiang strain) and lean...
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03-25-2011 06:34 PM
NMR-based metabonomic investigation of heat stress in myotubes reveals a time-depende
NMR-based metabonomic investigation of heat stress in myotubes reveals a time-dependent change in the metabolites.
Related Articles NMR-based metabonomic investigation of heat stress in myotubes reveals a time-dependent change in the metabolites.
J Agric Food Chem. 2010 May 26;58(10):6376-86
Authors: Straadt IK, Young JF, Bross P, Gregersen N, Oksbjerg N, Theil PK, Bertram HC
NMR-based metabonomics was applied to elucidate the time-dependent stress responses in mouse myotubes after heat exposure of either 42 or 45 degrees C for 1 h. Principal...
Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy.
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