Selenocysteine, the selenium-containing analogue of cysteine, is the twenty-first proteinogenic amino acid. Since its discovery almost fifty years ago, it has been exploited in unnatural systems even more often than in natural systems. Selenocysteine chemistry has attracted the attention of many chemists in the field of chemical biology owing to its high reactivity and resulting potential for various applications such as chemical modification, chemical protein (semi)synthesis, and protein folding, to name a few. In this Minireview, we will focus on the chemistry of selenium and selenocysteine and their utility in protein chemistry.Se how far we've come: Since its presence in proteins was discovered over 40 years ago, the singular properties of selenocysteine (Sec) have been exploited by protein chemists for a host of different applications. This Minireview summarizes the use of selenium and selenocysteine in various protein chemistry applications, including chemical modifications, protein synthesis, and protein folding.
[NMR paper] Selenium and Selenocysteine in Protein Chemistry
Selenium and Selenocysteine in Protein Chemistry
Selenocysteine, the selenium-containing analog of cysteine, is the twenty-first proteinogenic amino acid. Since its discovery almost fifty years ago, it has been exploited in unnatural systems more often than in natural systems. Selenocysteine chemistry has attracted the attention of many chemists in the field of chemical biology due to its high reactivity and resulting utility in various applications including chemical modification, chemical protein (semi-)synthesis, and protein folding, to name a few. In this review, we will focus on the...
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08-31-2017 12:14 AM
[NMR paper] Structure of Amorphous Selenium by 2D 77Se NMR Spectroscopy: An End to The Dilemma of Chain vs. Ring
Structure of Amorphous Selenium by 2D 77Se NMR Spectroscopy: An End to The Dilemma of Chain vs. Ring
Amorphous selenium, owing to its tremendous technological importance and perhaps to its chemical simplicity, has been studied for nearly a century and yet an unequivocal structural description of this material remains lacking in the literature to date. The primary controversy regarding the structure of a-Se relates to the relative fraction of Se atoms residing in infinite (Se) chains vs. in Se8 rings. Here we present the results of a two-dimensional solid-state 77Se nuclear magnetic...
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06-26-2017 08:42 AM
[NMR paper] SEAL by NMR: Glyco-Based Selenium-Labeled Affinity Ligands Detected by NMR Spectroscopy.
SEAL by NMR: Glyco-Based Selenium-Labeled Affinity Ligands Detected by NMR Spectroscopy.
Related Articles SEAL by NMR: Glyco-Based Selenium-Labeled Affinity Ligands Detected by NMR Spectroscopy.
Chemistry. 2014 Sep 5;
Authors: Hamark C, Landström J, Widmalm G
Abstract
We report a method for the screening of interactions between proteins and selenium-labeled carbohydrate ligands. SEAL by NMR is demonstrated with selenoglycosides binding to lectins where the selenium nucleus serves as an NMR-active handle and reports on binding...
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09-10-2014 11:24 AM
The antioxidant role of proteins containing selenium - Medical Xpress
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Medical Xpress
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The antioxidant role of proteins containing selenium
Medical Xpress
Rozovsky and her team used mass spectrometry and nuclear magnetic resonance spectroscopy to study selenium in redox biology, which the journal called a new approach that deepens scientific understanding of the chemical properties involved. Rozovsky ...
The antioxidant role of proteins containing selenium - Medical Xpress
Research on selenium in proteins published in national journal - University of Delaware
<img alt="" height="1" width="1" />
Research on selenium in proteins published in national journal
University of Delaware
Rozovsky and her team used mass spectrometry and nuclear magnetic resonance spectroscopy to study selenium in redox biology, which the journal called a new approach that deepens scientific understanding of the chemical properties involved. Rozovsky ...
Research on selenium in proteins published in national journal - University of Delaware
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Assistant or Associate Professor of Chemistry/ Organic Chemistry | SUNY College at Old Westbury
Assistant or Associate Professor of Chemistry/ Organic Chemistry | SUNY College at Old Westbury
US - NY - Old Westbury, Ph.D. in organic chemistry or bioorganic chemistry required. A significant background in organic synthesis and experience with its associated instrumentation, such as NMR, are strongly prefer
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Selenium and Selenocysteine in Protein Chemistry
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