[NMR paper] Investigating liquid-liquid phase separation of a monoclonal antibody using solution-state NMR spectroscopy: effect of Arg·Glu and Arg·HCl.
Investigating liquid-liquid phase separation of a monoclonal antibody using solution-state NMR spectroscopy: effect of Arg·Glu and Arg·HCl.
Investigating liquid-liquid phase separation of a monoclonal antibody using solution-state NMR spectroscopy: effect of Arg·Glu and Arg·HCl.
Mol Pharm. 2017 Jun 14;:
Authors: Kheddo P, Bramham JE, Dearman RJ, Uddin S, van der Walle CF, Golovanov AP
Abstract
Liquid-liquid phase separation (LLPS) of monoclonal antibody (mAb) formulations involves spontaneous separation into dense...
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06-15-2017 03:37 PM
[NMR paper] The nearest-neighbor effect on random-coil NMR chemical shifts demonstrated using a low-complexity amino-acid sequence.
The nearest-neighbor effect on random-coil NMR chemical shifts demonstrated using a low-complexity amino-acid sequence.
Related Articles The nearest-neighbor effect on random-coil NMR chemical shifts demonstrated using a low-complexity amino-acid sequence.
Protein Pept Lett. 2016 Sep 20;
Authors: Chen TC, Hsiao CL, Huang SJ, Huang JR
Abstract
In NMR experiments, the chemical shift is typically the first parameter measured and is a source of structural information for biomolecules. Indeed, secondary chemical shifts, the difference...
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09-23-2016 12:55 PM
[NMR paper] The Complexity of Protein Energy Landscapes Studied by Solution NMR Relaxation Dispersion Experiments.
The Complexity of Protein Energy Landscapes Studied by Solution NMR Relaxation Dispersion Experiments.
Related Articles The Complexity of Protein Energy Landscapes Studied by Solution NMR Relaxation Dispersion Experiments.
J Phys Chem B. 2015 Feb 13;
Authors: Khirich G, Loria JP
Abstract
The millisecond timescale motions in ribonuclease A (RNase A) were studied by solution NMR CPMG and off-resonance R1? relaxation dispersion experiments over a wide pH and temperature range. These experiments identify three separate protein...
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02-14-2015 03:52 PM
Phosphate–WaterInterplay Tunes Amorphous CalciumCarbonate Metastability: Spontaneous Phase Separation and Crystallizationvs Stabilization Viewed by Solid State NMR
Phosphate–WaterInterplay Tunes Amorphous CalciumCarbonate Metastability: Spontaneous Phase Separation and Crystallizationvs Stabilization Viewed by Solid State NMR
Shifi Kababya, Assaf Gal, Keren Kahil, Steve Weiner, Lia Addadi and Asher Schmidt
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja511869g/20150105/images/medium/ja-2014-11869g_0007.gif
Journal of the American Chemical Society
DOI: 10.1021/ja511869g
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA...
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01-06-2015 07:59 PM
[NMR paper] r TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing.
r TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing.
Related Articles r TPPM: Towards improving solid-state NMR two-pulse phase-modulation heteronuclear dipolar decoupling sequence by refocusing.
J Magn Reson. 2014 Apr 24;244C:68-73
Authors: Equbal A, Paul S, Mithu VS, Vinther JM, Nielsen NC, Madhu PK
Abstract
We present here a simple refocused modification, r TPPM, of the Two-Pulse Phase-Modulation (TPPM) heteronuclear decoupling method, which improves...
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06-01-2014 04:43 PM
Sweet complexity: Sugars and diabetes
Sweet complexity: Sugars and diabetes
http://www.spectroscopynow.com/common/images/thumbnails/13c0510ebe8.jpgNMR spectroscopy has been used to investigate dicarbonyl sugars formed inside the human body from the natural breakdown of the simple sugar, glucose. The implications for understanding the link with diabetes are discussed.
Source: Spectroscopynow.com
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02-03-2013 08:49 AM
[NMR paper] A solid-state NMR study of molecular mobility and phase separation in co-spray-dried
A solid-state NMR study of molecular mobility and phase separation in co-spray-dried protein-sugar particles.
Related Articles A solid-state NMR study of molecular mobility and phase separation in co-spray-dried protein-sugar particles.
Eur J Pharm Sci. 2005 May;25(1):105-12
Authors: Suihko EJ, Forbes RT, Apperley DC
Molecular mobility and physical form of co-spray-dried sugar-lysozyme formulations were evaluated. Co-spray-dried trehalose:lysozyme and sucrose:lysozyme formulations in 1:9, 1:1 and 9:1 ratios (w:w) were stored at 0% RH and 75%...
Relationship of Sequence and Phase Separation in ProteinLow-Complexity Regions
Linear Mode
