Introduction: There is evidence that sample treatment of blood-based biosamples may affect integral signals in nuclear magnetic resonance-based metabolomics. The presence of macromolecules in plasma/serum samples makes investigating low-molecular-weight metabolites challenging. It is particularly relevant in the targeted approach, in which absolute concentrations of selected metabolites are often quantified based on the area of integral signals. Since there are a few treatments of plasma/serum...
[NMR paper] Detection of Lung Cancer via Blood Plasma and (1)H-NMR Metabolomics: Validation by a Semi-Targeted and Quantitative Approach Using a Protein-Binding Competitor
Detection of Lung Cancer via Blood Plasma and (1)H-NMR Metabolomics: Validation by a Semi-Targeted and Quantitative Approach Using a Protein-Binding Competitor
Metabolite profiling of blood plasma, by proton nuclear magnetic resonance (¹H-NMR) spectroscopy, offers great potential for early cancer diagnosis and unraveling disruptions in cancer metabolism. Despite the essential attempts to standardize pre-analytical and external conditions, such as pH or temperature, the donor-intrinsic plasma protein concentration is highly overlooked. However, this is of utmost importance, since several...
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08-27-2021 03:49 PM
[NMR paper] 1H NMR-based metabolomics profiling and taste of boneless dry-cured hams during processing.
1H NMR-based metabolomics profiling and taste of boneless dry-cured hams during processing.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 1H NMR-based metabolomics profiling and taste of boneless dry-cured hams during processing.
Food Res Int. 2019 08;122:114-122
Authors: Zhang J, Yi Y, Pan D, Zhou G, Wang Y, Dang Y, He J, Li G, Cao J
Abstract
Boneless dry-cured hams were processed by raw material treatment (deboned and tumbled),...
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10-07-2020 07:29 AM
[NMR paper] Quantitative Metabolomic Profiling of Plasma, Urine and Liver Extracts by 1H NMR Spectroscopy Characterizes Different Stages of Atherosclerosis in Hamsters.
Quantitative Metabolomic Profiling of Plasma, Urine and Liver Extracts by 1H NMR Spectroscopy Characterizes Different Stages of Atherosclerosis in Hamsters.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Quantitative Metabolomic Profiling of Plasma, Urine and Liver Extracts by 1H NMR Spectroscopy Characterizes Different Stages of Atherosclerosis in Hamsters.
J Proteome Res. 2016 Aug 29;
Authors: Guo W, Jiang C, Yang L, Li T, Liu X, Jin M, Qu K, Chen H, Jin X, Liu H, Zhu...
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08-31-2016 02:34 PM
[NMR paper] Human plasma stability during handling and storage: impact on NMR metabolomics.
Human plasma stability during handling and storage: impact on NMR metabolomics.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.rsc.org-images-entities-char_z_RSClogo.gif Related Articles Human plasma stability during handling and storage: impact on NMR metabolomics.
Analyst. 2014 Mar 7;139(5):1168-77
Authors: Pinto J, Domingues MR, Galhano E, Pita C, Almeida Mdo C, Carreira IM, Gil AM
Abstract
This work contributes to fill in some existing gaps in the knowledge of human plasma degradability...
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08-29-2014 05:36 PM
[NMR paper] (1)H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease.
(1)H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease.
(1)H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease.
PLoS One. 2014 Jan 20;9(1):e85445
Authors: Kim JA, Choi HJ, Kwon YK, Ryu do H, Kwon TH, Hwang GS
Abstract
Chronic kidney disease (CKD) is characterized by the gradual loss of the kidney function to excrete wastes and fluids from the blood. (1)H NMR-based metabolomics was exploited to investigate the altered metabolic pattern in rats with CKD induced by surgical...
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01-28-2014 11:53 AM
[NMR paper] NMR metabolomics profiling of blood plasma mimics shows that medium- and long-chain fatty acids differently release metabolites from human serum albumin.
NMR metabolomics profiling of blood plasma mimics shows that medium- and long-chain fatty acids differently release metabolites from human serum albumin.
Related Articles NMR metabolomics profiling of blood plasma mimics shows that medium- and long-chain fatty acids differently release metabolites from human serum albumin.
J Magn Reson. 2013 Dec 12;239C:34-43
Authors: Jupin M, Michiels PJ, Girard FC, Spraul M, Wijmenga SS
Abstract
Metabolite profiling by NMR of body fluids is increasingly used to successfully differentiate patients...
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01-01-2014 03:05 PM
[NMR paper] NMR Metabolomics Profiling of Blood Plasma Mimics shows that Medium- and Long-chain Fatty Acids Differently Release Metabolites from Human Serum Albumin
NMR Metabolomics Profiling of Blood Plasma Mimics shows that Medium- and Long-chain Fatty Acids Differently Release Metabolites from Human Serum Albumin
Publication date: Available online 12 December 2013
Source:Journal of Magnetic Resonance</br>
Author(s): M.D. Jupin , P.J. Michiels , F.C. Girard , M. Spraul , S.S. Wijmenga</br>
Metabolite profiling by NMR of body fluids is increasingly used to successfully differentiate patients from healthy individuals. Metabolites and their concentrations are direct reporters of body biochemistry. However, in blood plasma...
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12-12-2013 11:39 PM
[NMR paper] NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T1 AM treatment.
NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T1 AM treatment.
Related Articles NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T1 AM treatment.
Obesity (Silver Spring). 2013 Mar 20;
Authors: Haviland JA, Reiland H, Butz DE, Tonelli M, Porter WP, Zucchi R, Scanlan TS, Chiellini G, Assadi-Porter FM
Abstract
OBJECTIVE: 3-iodothyronamine (T1 AM), an analog of thyroid hormone,is a recently discovered fast-acting endogenous metabolite. High...
Quantitative plasma profiling by 1H NMR-based metabolomics: impact of sample treatment
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