The N-terminal region of the huntingtin protein, encoded by exon-1 (htt^(ex1)) and containing an expanded polyglutamine tract, forms fibrils that accumulate in neuronal inclusion bodies, resulting in Huntington's disease. We previously showed that reversible formation of a sparsely populated tetramer of the N-terminal amphiphilic domain, comprising a dimer of dimers in a four-helix bundle configuration, occurs on the microsecond timescale and is an essential prerequisite for subsequent...
[NMR paper] Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins.
Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins.
Robust Cell-Free Expression of Sub-Pathological and Pathological Huntingtin Exon-1 for NMR Studies. General Approaches for the Isotopic Labeling of Low-Complexity Proteins.
Biomolecules. 2020 Oct 19;10(10):
Authors: Morató A, Elena-Real CA, Popovic M, Fournet A, Zhang K, Allemand F, Sibille N, Urbanek A, Bernadó P
Abstract
The high-resolution structural...
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[ASAP] Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR
Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR
Alberto Ceccon, Thomas Schmidt, Vitali Tugarinov, Samuel A. Kotler, Charles D. Schwieters, G. Marius Clore
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.8b02619/20180514/images/medium/ja-2018-026194_0005.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.8b02619
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http://feeds.feedburner.com/~r/acs/jacsat/~4/NazZqWqOVC4
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Disordered Nanostructure in Huntingtin InteractingProtein K Acts as a Stabilizing Switch To Prevent Protein Aggregation
Disordered Nanostructure in Huntingtin InteractingProtein K Acts as a Stabilizing Switch To Prevent Protein Aggregation
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00776/20180213/images/medium/bi-2017-00776d_0008.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00776
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[NMR paper] Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A*Solution NMR Perspective.
Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A*Solution NMR Perspective.
Related Articles Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A*Solution NMR Perspective.
J Am Chem Soc. 2017 Jan 13;:
Authors: Baias M, Smith PE, Shen K, Joachimiak LA, ?erko S, Ko?mi?ski W, Frydman J, Frydman L
Abstract
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Structureand Dynamics of the Huntingtin Exon-1N-Terminus: A*Solution NMR Perspective
Structureand Dynamics of the Huntingtin Exon-1N-Terminus: A*Solution NMR Perspective
Maria Baias, Pieter E. S. Smith, Koning Shen, Lukasz A. Joachimiak, Szymon Z?erko, Wiktor Koz?min?ski, Judith Frydman and Lucio Frydman
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.6b10893/20170113/images/medium/ja-2016-108934_0011.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.6b10893
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http://feeds.feedburner.com/~r/acs/jacsat/~4/6vVAqMsGYCM
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Difference between Extra- and IntracellularT1Values of Carboxylic Acids Affects the Quantitative Analysis of Cellular Kinetics by Hyperpolarized NMR
From The DNP-NMR Blog:
Difference between Extra- and IntracellularT1Values of Carboxylic Acids Affects the Quantitative Analysis of Cellular Kinetics by Hyperpolarized NMR
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Karlsson, M., et al., Difference between Extra- and IntracellularT1Values of Carboxylic Acids Affects the Quantitative Analysis of Cellular Kinetics by Hyperpolarized NMR. Angewandte Chemie, 2016. 128(43): p. 13765-13768.
http://dx.doi.org/10.1002/ange.201607535