Quantification of Biopharmaceutically Relevant Nonionic Surfactant Excipients Using Benchtop qNMR
 

Quantification of Biopharmaceutically Relevant Nonionic Surfactant Excipients Using Benchtop qNMR

Nonionic surfactant excipients (NISEs) are commonly added to biologics formulations to mitigate the effects of stress incurred by the active biotherapeutic during manufacturing, transport, and storage. During manufacturing, NISEs are added by dilution of a stock solution directly into a protein formulation, and their accurate addition is critical in maintaining the quality and integrity of the drug product and thus ensuring patient safety. This is especially true for the common NISEs,...

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