Related ArticlesProtein NMR extends into new fields of structural biology.
Curr Opin Chem Biol. 1997 Oct;1(3):359-64
Authors: Cooke RM
Advances in protein NMR have opened new doors for the understanding of macromolecular structure and interactions. Isotope-labelling approaches have extended the size limit for structure determination, the mapping of protein-ligand interactions is now widely used and has led to a new drug discovery approach, pathways of protein folding processes can be followed, and the structures of molecules from membranes can be determined.
NMR Structural Biology and Biophysics of Protein:Protein Complexes, National Cancer Institute, Frederick, MD, United States
NMR Structural Biology and Biophysics of Protein:Protein Complexes, National Cancer Institute, Frederick, MD, United States
Postdoctoral positions are available in the Macromolecular NMR section of the Structural Biophysics Laboratory headed by Dr. R. Andrew Byrd at the National Cancer Institute. The Byrd lab combines NMR structural biology & Small Angle Xray Scattering (...
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11-15-2011 11:36 PM
Measurement of protein unfolding/refolding kinetics and structural characterization of hidden intermediates by NMR relaxation dispersion [Biophysics and Computational Biology]
Measurement of protein unfolding/refolding kinetics and structural characterization of hidden intermediates by NMR relaxation dispersion
Meinhold, D. W., Wright, P. E....
Date: 2011-05-31
Detailed understanding of protein function and malfunction hinges on the ability to characterize transiently populated states and the transitions between them. Here, we use 15N, , and 13CO NMR R2 relaxation dispersion to investigate spontaneous unfolding and refolding events of native apomyoglobin. Above pH 5.0, dispersion is dominated by processes involving fluctuations of the F-helix region, which...
Structural biology: Breaking the protein rules - Nature.com (subscription)
Structural biology: Breaking the protein rules - Nature.com (subscription)
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Nature.com (subscription)
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Structural biology: Breaking the protein rules
Nature.com (subscription)
As is Martin Blackledge, an NMR spectroscopist at the Institute of Structural Biology in Grenoble, France, who compares the excitement now to that surrounding the first crystal protein structures in the 1950s. "Every new case is fascinating at the ...
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03-10-2011 04:29 AM
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States
Research Scientist Position in the Cryo-Electron Microscopy Facility at the New York Structural Biol - New York Structural Biology Center - New York, NY, United States
The New York Structural Biology Center (NYSBC) seeks an experienced electron microscopist to join the staff of its Cryo-Electron Microscope Facility (http://cryoem.nysbc.org). The NYSBC is shared center that supports state-of-the-art research in cryo-EM, NMR, and X-ray. Cryo-EM facilities include four transmission electron microscopes and a new d...
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01-26-2011 04:21 AM
Structural Biology Scores With Protein Snapshot
Structural Biology Scores With Protein Snapshot
(July 12, 2009) -- Investigators have used nuclear magnetic resonance methods to determine the structure of the largest membrane-spanning protein to date. The group's ability to determine the NMR structure of the bacterial protein diacylglycerol kinase, reported in the journal Science, suggests that similar methods can now be used to study the stru
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08-19-2010 01:47 PM
NMR in Structural Biology - Alessandro Pintar, Protein Structure and Bioinformatics, ICGEB, Trieste
Nuclear Magnetic Resonance in Structural Biology - Alessandro Pintar, Protein Structure and Bioinformatics, ICGEB, Trieste
Thanks to advancements both in the theory and in the instrumentation, Nuclear Magnetic Resonance (NMR) has widened its use from small organic molecules to oligosaccharides, peptides, proteins, and nucleic acids. Together with X-ray crystallography, NMR is the only technique that can provide structural information at the atomic level. However, applications of NMR are not limited to 3D structure calculation: it can be used to study flexible biomolecules (peptides,...
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09-16-2008 01:50 AM
Fundamentals of Protein NMR Spectroscopy (Focus on Structural Biology) - Gordon S. Rule, T. Kevin Hitchens (2005)
Fundamentals of Protein NMR Spectroscopy (Focus on Structural Biology)
By Gordon S. Rule & T. Kevin Hitchens (2005)
Amazon Book description
NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a...