Nuclear magnetic resonance (NMR) spectroscopy is a versatile biophysical technique with wide applicability in drug discovery research, particularly for the detection and characterization of molecular interactions. This review highlights in a comprehensive manner the aspects of biomolecular NMR which are most beneficial for pharmaceutical research and presents them as contributions to the different stages of a drug discovery program: target selection, assay development, lead generation and lead optimization. Emphasis is put on the concept of the particular NMR application, rather than on technical details, and on recent examples. Finally, an appendix of frequently asked questions is given.
Protein NMR/Biophysics Research Associate (BS/MS)
The candidate will join a state-of-the art protein structure unit at the Novartis Cambridge, MA USA campus as part of the protein NMR team. Core responsibilities will include sample preparation logistics and data collection to support both fragment based drug discovery and HTS hit validation. In addition, the candidate will participate in the maintenance and incorporation of new technologies to support these efforts. Opportunities for scientific growth in the interpretation and design of experiments will be available. The successful candidate will have demonstrated successes in working in a...
Protein NMR in biomedical research.
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