Porphyrinic compounds are widespread in nature and play key roles in biological processes such as oxygen transport in blood, enzymatic redox reactions or photosynthesis. In addition, both naturally derived as well as synthetic porphyrinic compounds are extensively explored for biomedical and technical applications such as photodynamic therapy (PDT) or photovoltaic systems, respectively. Their unique electronic structures and photophysical properties make this class of compounds so interesting...
Conformational control of nonplanar free base porphyrins: towards bifunctional catalysts of tunable basicity #DNPNMR
From The DNP-NMR Blog:
Conformational control of nonplanar free base porphyrins: towards bifunctional catalysts of tunable basicity #DNPNMR
Roucan, M., M. Kielmann, S. J. Connon, S. S. R. Bernhard, and M. O. Senge. “Conformational Control of Nonplanar Free Base Porphyrins: Towards Bifunctional Catalysts of Tunable Basicity.” Chemical Communications 54, no. 1 (2018): 26–29.
https://doi.org/10.1039/C7CC08099A.
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03-31-2020 04:27 AM
Trimethylsilyl tag for probing proteinâ??ligand interactions by NMR
Trimethylsilyl tag for probing proteinâ??ligand interactions by NMR
Abstract
Proteinâ??ligand titrations can readily be monitored with a trimethylsilyl (TMS) tag. Owing to the intensity, narrow line shape and unique chemical shift of a TMS group, dissociation constants can be determined from straightforward 1D 1H-NMR spectra not only in the fast but also in the slow exchange limit. The tag is easily attached to cysteine residues and a sensitive reporter of ligand binding also at sites where it does not interfere with ligand binding or catalytic...
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03-21-2018 04:04 PM
[NMR paper] Exploiting Uniformly (13)C-Labeled Carbohydrates for Probing Carbohydrate-Protein Interactions by NMR Spectroscopy.
Exploiting Uniformly (13)C-Labeled Carbohydrates for Probing Carbohydrate-Protein Interactions by NMR Spectroscopy.
Exploiting Uniformly (13)C-Labeled Carbohydrates for Probing Carbohydrate-Protein Interactions by NMR Spectroscopy.
J Am Chem Soc. 2017 Apr 13;:
Authors: Nestor G, Anderson T, Oscarson S, Gronenborn AM
Abstract
NMR of a uniformly (13)C-labeled carbohydrate was used to elucidate the atomic details of a sugar-protein complex. The structure of the (13)C-labeled Man?(1-2)Man?(1-2)Man?OMe trisaccharide ligand when bound...
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04-14-2017 10:27 AM
[NMR paper] Amino acid conservation and interactions in rhodopsin: Probing receptor activation by NMR spectroscopy.
Amino acid conservation and interactions in rhodopsin: Probing receptor activation by NMR spectroscopy.
Related Articles Amino acid conservation and interactions in rhodopsin: Probing receptor activation by NMR spectroscopy.
Biochim Biophys Acta. 2013 Oct 29;
Authors: Pope A, Eilers M, Reeves PJ, Smith SO
Abstract
Rhodopsin is a classical two-state G protein-coupled receptor (GPCR). In the dark, its 11-cis retinal chromophore serves as an inverse agonist to lock the receptor in an inactive state. Retinal-protein and protein-protein...
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11-05-2013 06:53 PM
[NMR paper] Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques.
Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques.
Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques.
Molecules. 2013;18(9):11467-84
Authors: Russo L, Raiola L, Campitiello MA, Magrě A, Fattorusso R, Malgieri G, Pappalardo G, La Mendola D, Isernia C
Abstract
Many proteins perform essential biological functions by means of regions that lacking specific organized structure exist as an ensemble of interconverting transient conformers. The characterization of such...
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09-19-2013 02:19 PM
[NMR paper] Magic-Angle-Spinning NMR Techniques for Measuring Long-Range Distances in Biological Macromolecules.
Magic-Angle-Spinning NMR Techniques for Measuring Long-Range Distances in Biological Macromolecules.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Magic-Angle-Spinning NMR Techniques for Measuring Long-Range Distances in Biological Macromolecules.
Acc Chem Res. 2013 Feb 7;
Authors: Hong M, Schmidt-Rohr K
Abstract
The determination of molecular structures using solid-state NMR spectroscopy requires distance measurement through nuclear-spin dipole-dipole couplings....
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02-09-2013 12:18 AM
[NMR paper] Probing carbohydrate-protein interactions by high-resolution NMR spectroscopy.
Probing carbohydrate-protein interactions by high-resolution NMR spectroscopy.
Related Articles Probing carbohydrate-protein interactions by high-resolution NMR spectroscopy.
Adv Exp Med Biol. 1998;435:29-38
Authors: Homans SW, Field RA, Milton MJ, Probert M, Richardson JM
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11-17-2010 11:06 PM
[NMR paper] Probing the structure and interactions of crystallin proteins by NMR spectroscopy.
Probing the structure and interactions of crystallin proteins by NMR spectroscopy.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Probing the structure and interactions of crystallin proteins by NMR spectroscopy.
Prog Retin Eye Res. 1999 Jul;18(4):431-62
Authors: Carver JA
The lens is composed primarily of proteins, the crystallins, at high concentration whose structure and interactions are responsible for lens transparency. As there is no protein turnover in the...
Probing the Interactions of Porphyrins with Macromolecules Using NMR Spectroscopy Techniques
Linear Mode
