Related ArticlesProbing the cation binding modes of macrocyclic HCV protease inhibitor BILN 2061 by multinuclear NMR.
J Pharm Biomed Anal. 2012 Nov;70:609-13
Authors: Busacca CA, Jones PJ, Campbell SJ, Saha AK, Gonnella NC, Senanayake CH
Abstract
The ability of the macrocyclic HCV protease inhibitor BILN 2061 to bind different classes of cations has been studied by (15)N, (13)C, and (1)H NMR. (15)N NMR experiments were performed at natural abundance or with isotopically labeled materials. Three classes of cations: alkali metals, alkaline earth metals, and transition metals, were examined, using two members of each class. The behavior of each cation class was found to be different, and provided insight into how metal ions interact with the molecular scaffold. These specific interactions were uncovered by examining coordination shifts, NOE correlations, and line broadening across all three nuclei.
Probing Cation and VacancyOrdering in the Dry andHydrated Yttrium-Substituted BaSnO3 Perovskite by NMR Spectroscopyand First Principles Calculations: Implications for Proton Mobility
Probing Cation and VacancyOrdering in the Dry andHydrated Yttrium-Substituted BaSnO3 Perovskite by NMR Spectroscopyand First Principles Calculations: Implications for Proton Mobility
Lucienne Buannic, Fre?de?ric Blanc, Derek S. Middlemiss and Clare P. Grey
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja304712v/aop/images/medium/ja-2012-04712v_0012.gif
Journal of the American Chemical Society
DOI: 10.1021/ja304712v
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/L9351EyeKM8
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Probing the cation binding modes of macrocyclic HCV protease inhibitor BILN 2061 by multinuclear NMR.
Linear Mode
