NMR paper Platinum-Metformin Conjugates Acting as Promising PD-L1 Inhibitors through the AMP-Activated Protein Kinase Mediated Lysosomal Degradation Pathway

		BioNMR > Educational resources > Journal club
[NMR paper] Platinum-Metformin Conjugates Acting as Promising PD-L1 Inhibitors through the AMP-Activated Protein Kinase Mediated Lysosomal Degradation Pathway

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

Thread Tools

Search this Thread

Rate Thread

Display Modes

10-26-2024, 08:05 AM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,732

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Platinum-Metformin Conjugates Acting as Promising PD-L1 Inhibitors through the AMP-Activated Protein Kinase Mediated Lysosomal Degradation Pathway

Platinum-Metformin Conjugates Acting as Promising PD-L1 Inhibitors through the AMP-Activated Protein Kinase Mediated Lysosomal Degradation Pathway

Angewandte Chemie International Edition, EarlyView.

More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop \| Proceedings of the National Academy of Sciences - pnas.org Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop \| Proceedings of the National Academy of Sciences - pnas.org Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop \| Proceedings of the National Academy of Sciences pnas.org Read here	nmrlearner	Online News	0	10-21-2022 07:28 PM
[ASAP] Inducing Protein Degradation to Overcome Resistance to Kinase Inhibitors Inducing Protein Degradation to Overcome Resistance to Kinase Inhibitors https://pubs.acs.org/cms/10.1021/acs.biochem.2c00223/asset/images/medium/bi2c00223_0002.gif Biochemistry DOI: 10.1021/acs.biochem.2c00223 More...	nmrlearner	Journal club	0	06-17-2022 08:24 AM
Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop \| Proceedings of the National Academy of Sciences - pnas.org Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop \| Proceedings of the National Academy of Sciences - pnas.org Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop \| Proceedings of the National Academy of Sciences pnas.org Read here	nmrlearner	Online News	0	06-14-2022 04:36 AM
[ASAP] Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.1c00330/20210927/images/medium/bi1c00330_0002.gif Biochemistry DOI: 10.1021/acs.biochem.1c00330 http://feeds.feedburner.com/~r/acs/bichaw/~4/joOGR6eQNhs More...	nmrlearner	Journal club	0	09-27-2021 10:14 PM
[ASAP] Delineating Heme-Mediated versus Direct Protein Oxidation in Peroxidase-Activated Cytochrome c by Top-Down Mass Spectrometry Delineating Heme-Mediated versus Direct Protein Oxidation in Peroxidase-Activated Cytochrome c by Top-Down Mass Spectrometry https://pubs.acs.org/na101/home/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.0c00609/20201005/images/medium/bi0c00609_0008.gif Biochemistry DOI: 10.1021/acs.biochem.0c00609 http://feeds.feedburner.com/~r/acs/bichaw/~4/2ivTObBeW6g More...	nmrlearner	Journal club	0	10-07-2020 07:29 AM
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex - Science Magazine Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex - Science Magazine Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex Science Magazine Read here	nmrlearner	Online News	0	04-28-2020 05:11 AM
Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex - Science Magazine Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex - Science Magazine Structural basis of ER-associated protein degradation mediated by the Hrd1 ubiquitin ligase complex Science Magazine Read here	nmrlearner	Online News	0	04-23-2020 11:10 PM
[NMR paper] NMR backbone assignment of the mitogen-activated protein (MAP) kinase p38. NMR backbone assignment of the mitogen-activated protein (MAP) kinase p38. Related Articles NMR backbone assignment of the mitogen-activated protein (MAP) kinase p38. J Biomol NMR. 2005 Jun;32(2):175 Authors: Vogtherr M, Saxena K, Grimme S, Betz M, Schieborr U, Pescatore B, Langer T, Schwalbe H	nmrlearner	Journal club	0	11-25-2010 08:21 PM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off