[NMR paper] Parkin prevents cortical atrophy and A?-induced alterations of brain metabolism: 像C NMR and magnetic resonance imaging studies in AD models.
Related ArticlesParkin prevents cortical atrophy and A?-induced alterations of brain metabolism: 像C NMR and magnetic resonance imaging studies in AD models.
Neuroscience. 2012 Dec 6;225:22-34
Authors: Algarzae N, Hebron M, Miessau M, Moussa CE
Abstract
Alzheimer's disease (AD) is a neurodegenerative aging disorder characterized by extracellular A? plaques and intraneuronal neurofibrillary tangles. We conducted longitudinal studies to examine the effects of A? on brain amino acid metabolism in lentiviral A?(1-42) gene transfer animals and transgenic AD mice. We also performed lentiviral parkin gene delivery to determine the effects of A? clearance in AD models. A?(1-42) activated mTOR signaling, and increased 4E-BP phosphorylation. A?(1-42) increased the synthesis of glutamate and aspartate, but not glutamine, leucine and isoleucine, but an increase in leucine and isoleucine levels was concurrent with diminution of neurotransmitters. Additionally, A?(1-42) attenuated mitochondrial tricarboxylic acid (TCA) cycle activity and decreased synthesis of its by-products. Glutamate levels increased prior to lactate accumulation, suggesting oxidative stress. Importantly, parkin reversed the effects of A?(1-42) on amino acid levels, prevented TCA cycle impairment and protected against glutamate toxicity. Cortical atrophy was observed in aged 3xTg-AD mice, while parkin expression was associated with reduced atrophy. Similarly, A?(1-42) resulted in significant cell loss, pronounced astrogliosis and cortical atrophy and parkin reduced astrogliosis and reversed A?(1-42) effects on cell loss and cortical atrophy. Taken together these data suggest that parkin prevents amyloid-induced alteration of brain metabolism and may be used as a therapeutic target to limit neuronal loss in AD.
[NMR paper] Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jan 17;
Authors: Xue S, Qiao J, Pu F, Cameron M, Yang JJ
Abstract
Magnetic...
In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field
In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field
Publication year: 2011
Source:Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 59, Issue 4</br>
Xiao-Hong Zhu, Wei Chen</br>
</br>
</br></br>
nmrlearner
Journal club
0
03-09-2012 09:16 AM
In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field
In vivo oxygen-17 NMR for imaging brain oxygen metabolism at high field
Publication year: 2011
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, In Press, Accepted Manuscript, Available online 23 April 2011</br>
Xiao-Hong, Zhu , Wei, Chen</br>
*Highlights:*? This article reviews the developments of in vivo 17O NMR imaging in brain research. ? In vivo 17O NMR imaging has improved significantly at high/ultrahigh field. ? In vivo 17O NMR can noninvasively image brain oxygen metabolism and perfusion. ? In vivo 17O NMR is useful for mapping the functional change in oxygen...
Characterization of (1)H NMR signal in human cortical bone for magnetic resonance ima
Characterization of (1)H NMR signal in human cortical bone for magnetic resonance imaging.
Characterization of (1)H NMR signal in human cortical bone for magnetic resonance imaging.
Magn Reson Med. 2010 Sep;64(3):680-7
Authors: Horch RA, Nyman JS, Gochberg DF, Dortch RD, Does MD
Recent advancements in MRI have enabled clinical imaging of human cortical bone, providing a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to conventional X-ray-based diagnostics. In human cortical bone, MRI is...
nmrlearner
Journal club
0
09-02-2010 03:58 PM
[NMR paper] 31P NMR studies of phosphate metabolism in the ovulatory process induced by gonadotro
31P NMR studies of phosphate metabolism in the ovulatory process induced by gonadotropins in perfused rabbit ovary.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_120x27.gif Related Articles 31P NMR studies of phosphate metabolism in the ovulatory process induced by gonadotropins in perfused rabbit ovary.
NMR Biomed. 1999 Jun;12(4):249-55
Authors: Tanaka K, Mizukami A, Kojima N, Ishikawa M
The concentrations of phosphate metabolites were measured in perfused...