Abstract
The development of multidimensional NMR spectroscopy enabled an explosion of structural and dynamical investigations on proteins and other biomacromolecules. Practical limitations on data sampling, based on the Jeener paradigm of parametric sampling of indirect time domains, have long placed limits on resolution in the corresponding frequency dimensions. The emergence of nonuniform sampling (NUS) in indirect time dimensions circumvents those limitations, affording high resolution spectra from short data records collected in practically realized measurement times. In addition to substantially improved resolution, NUS can also be exploited to improve sensitivity, with gains comparable to those obtained using cryogenically cooled probes. We describe a general approach for acquiring and processing multidimensional NUS NMR data for improving sensitivity.
PMID: 29522805 [PubMed - as supplied by publisher]
[NMR paper] Improving resolution in multidimensional NMR using random quadrature detection with compressed sensing reconstruction.
Improving resolution in multidimensional NMR using random quadrature detection with compressed sensing reconstruction.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Improving resolution in multidimensional NMR using random quadrature detection with compressed sensing reconstruction.
J Biomol NMR. 2017 Jun;68(2):67-77
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01-14-2018 12:38 AM
Sensitivity of nonuniform sampling NMR
From The DNP-NMR Blog:
Sensitivity of nonuniform sampling NMR
This is not an article directly related to DNP, however, non-uniform sampling is another great technique to enhance sensitivity in a NMR experiment. The concept can easily combined with DNP to yield even higher sensitivity enhancement factors.
[NMR paper] Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range.
Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range.
J Biomol NMR. 2014 Jun;59(2):57-73
Authors: Suiter CL, Paramasivam S, Hou G, Sun S, Rice D, Hoch JC, Rovnyak D, Polenova T
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12-31-2014 06:44 PM
Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR
Nonuniform sampling and non-Fourier signal processing methods in multidimensional NMR
Publication date: Available online 13 October 2014
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Author(s): Mehdi Mobli , Jeffrey C. Hoch</br>
Beginning with the introduction of Fourier Transform NMR by Ernst and Anderson in 1966, time domain measurement of the impulse response (the free induction decay, FID) consisted of sampling the signal at a series of discrete intervals. For compatibility with the discrete Fourier transform (DFT), the intervals are kept...
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10-14-2014 04:35 AM
Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range
Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range
Abstract
Recently, we have demonstrated that considerable inherent sensitivity gains are attained in MAS NMR spectra acquired by nonuniform sampling (NUS) and introduced maximum entropy interpolation (MINT) processing that assures the linearity of transformation between the time and frequency domains. In this report, we examine the utility of the NUS/MINT approach in multidimensional datasets possessing high...
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06-19-2014 10:21 PM
Knowledge-based nonuniform sampling in multidimensional NMR
Knowledge-based nonuniform sampling in multidimensional NMR
Abstract The full resolution afforded by high-field magnets is rarely realized in the indirect dimensions of multidimensional NMR experiments because of the time cost of uniformly sampling to long evolution times. Emerging methods utilizing nonuniform sampling (NUS) enable high resolution along indirect dimensions by sampling long evolution times without sampling at every multiple of the Nyquist sampling interval. While the earliest NUS approaches matched the decay of sampling density to the decay of the signal envelope, recent...
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06-06-2011 12:53 AM
Grid computing for improving conformational sampling in NMR structure calculation.
Grid computing for improving conformational sampling in NMR structure calculation.
Grid computing for improving conformational sampling in NMR structure calculation.
Bioinformatics. 2011 May 5;
Authors: Mareuil F, Blanchet C, Malliavin TE, Nilges M
MOTIVATION: Methods for automatic NMR structure determination need to face a high level of ambiguity encountered in NMR spectra recorded by solid-state NMR and by solution NMR of partially unfolded proteins, leading to time-consuming calculations. The software package Ambiguous Restraints for Iterative...
Nonuniform Sampling in Multidimensional NMR for Improving Spectral Sensitivity.
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