[NMR paper] Noninvasive characterization (EPR, ?CT, NMR) of 3D PLA electrospun fiber sponges for controlled drug delivery.

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Noninvasive characterization (EPR, ?CT, NMR) of 3D PLA electrospun fiber sponges for controlled drug delivery.

Related Articles Noninvasive characterization (EPR, ?CT, NMR) of 3D PLA electrospun fiber sponges for controlled drug delivery.

Int J Pharm X. 2020 Dec;2:100055

Authors: Zech J, Mader M, Gündel D, Metz H, Odparlik A, Agarwal S, Mäder K, Greiner A

Abstract
Highly porous 3D-scaffolds, made from cut, electrospun PLA fibers, are relatively new and promising systems for controlled drug-delivery applications. Because knowledge concerning fundamental processes of drug delivery from those scaffolds is limited, we noninvasively characterized drug-loading and drug-release mechanisms of these polymer-fiber sponges (PFS). We screened simplified PFS-implantation scenarios with EPR and ?CT to quantify and 3D-visualize the absorption of model-biofluids and an oil, a possible drug-loading liquid. Saturation of PFS (6*×*8*mm, h x d) is governed by the high hydrophobicity of the material and air-entrapment. It required up to 45*weeks for phosphate-buffered saline and 11*weeks for a more physiological, surface-active protein-solution, indicating the slow fluid-uptake of PFS as an effective mechanism to substantially prolong the release of a drug incorporated within the scaffold. Medium-chain triglycerides, as a good wetting liquid, saturated PFS within seconds, suggesting PFS potential to serve as carrier-vessels for immobilizing hydrophobic drug-solutions to define a liquid's 3D-interface. Oil-retention under mechanical stress was therefore investigated. 1H NMR permitted insights into PFS-oil interaction, confirming surface-relaxation and restricted diffusion; both did not influence drug release from oil-loaded PFS. Results facilitate better understanding of PFS and their potential use in drug delivery.


PMID: 32984812 [PubMed]



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