The accelerated acquisition of multidimensional NMR spectra using sparse non-uniform sampling (NUS) has been widely adopted in recent years. The key concept in NUS is that a major part of the data is omitted during measurement, and then reconstructed using, for example, compressed sensing (CS) methods. CS requires spectra to be compressible, that is, they should contain relatively few "significant" points. The more compressible the spectrum, the fewer experimental NUS points needed in order for...
Non-uniform sampling of similar NMR spectra and its application to studies of the interaction between alpha-synuclein and liposomes
Non-uniform sampling of similar NMR spectra and its application to studies of the interaction between alpha-synuclein and liposomes
Abstract
The accelerated acquisition of multidimensional NMR spectra using sparse non-uniform sampling (NUS) has been widely adopted in recent years. The key concept in NUS is that a major part of the data is omitted during measurement, and then reconstructed using, for example, compressed sensing (CS) methods. CS requires spectra to be compressible, that is, they should contain relatively few â??significantâ?? points....
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05-27-2023 02:53 PM
NMR unveils an N-terminal interaction interface on acetylated-{alpha}-synuclein monomers for recruitment to fibrils [Biophysics and Computational Biology]
NMR unveils an N-terminal interaction interface on acetylated-{alpha}-synuclein monomers for recruitment to fibrils
Xue Yang, Baifan Wang, Cody L. Hoop, Jonathan K. Williams, Jean Baum...
Date: 2021-04-26
Amyloid fibril formation of ?-synuclein (?S) is associated with multiple neurodegenerative diseases, including Parkinson’s disease (PD). Growing evidence suggests that progression of PD is linked to cell-to-cell propagation of ?S fibrils, which leads to seeding of endogenous intrinsically disordered monomer via templated elongation and secondary nucleation. A molecular understanding...
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04-27-2021 10:40 AM
Joint non-uniform sampling of all incremented time delays for quicker acquisition in protein relaxation studies
Joint non-uniform sampling of all incremented time delays for quicker acquisition in protein relaxation studies
Abstract
NMR relaxometry plays crucial role in studies of protein dynamics. The measurement of longitudinal and transverse relaxation rates of \(^{15}\) N is the main source of information on backbone motions. However, even the most basic approach exploiting a series of \(^{15}\) ...
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05-16-2017 06:53 AM
A non-uniform sampling approach enables studies of dilute and unstable proteins
A non-uniform sampling approach enables studies of dilute and unstable proteins
Abstract
NMR spectroscopy is a powerful method in structural and functional analysis of macromolecules and has become particularly prevalent in studies of protein structure, function and dynamics. Unique to NMR spectroscopy is the relatively low constraints on sample preparation and the high level of control of sample conditions. Proteins can be studied in a wide range of buffer conditions, e.g. different pHs and variable temperatures, allowing studies of proteins under...
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02-11-2017 12:49 PM
[NMR paper] A molecular dynamics simulations-based interpretation of NMR multidimensional heteronuclear spectra of alpha-synuclein/dopamine adducts.
A molecular dynamics simulations-based interpretation of NMR multidimensional heteronuclear spectra of alpha-synuclein/dopamine adducts.
Related Articles A molecular dynamics simulations-based interpretation of NMR multidimensional heteronuclear spectra of alpha-synuclein/dopamine adducts.
Biochemistry. 2013 Aug 21;
Authors: Dibenedetto D, Rossetti G, Caliandro R, Carloni P
Abstract
Multidimensional heteronuclear NMR spectroscopy provides valuable structural information on adducts between naturally unfolded proteins and their ligands....
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08-24-2013 04:53 PM
[NMR paper] Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization.
Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization.
PLoS One. 2013;8(1):e53487
Authors: ...
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02-03-2013 10:19 AM
An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR
An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR
June 2012
Publication year: 2012
Source:Journal of Magnetic Resonance, Volume 219</br>
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Non-uniform weighted sampling (NUWS) is a sampling strategy, related to non-uniform sampling (NUS) in the limit of long acquisition times, in which each indirect increment of a multidimensional spectrum is sampled multiple times according to some weighting function. As the spectrum is fully sampled it can be processed in a conventional manner by the...
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02-03-2013 10:13 AM
An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR
An analysis of NMR sensitivity enhancements obtained using non-uniform weighted sampling, and the application to protein NMR
Publication year: 2012
Source:Journal of Magnetic Resonance</br>
Christopher A. Waudby, John Christodoulou</br>
Non-uniform weighted sampling (NUWS) is a sampling strategy, related to non-uniform sampling (NUS) in the limit of long acquisition times, in which each indirect increment of a multidimensional spectrum is sampled multiple times according to some weighting function. As the spectrum is fully sampled it can be processed in a conventional...
Non-uniform sampling of similar NMR spectra and its application to studies of the interaction between alpha-synuclein and liposomes
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