The Min system is a key spatial regulator of cell division in rod-shaped bacteria and the first FtsZ negative modulator to be recognized. Nevertheless, despite extensive genetic and in vitro studies, the molecular mechanism used by MinC to inhibit Z-ring formation remains incompletely understood. The crystallization of FtsZ in complex with other negative regulators such as SulA and MciZ has provided important structural information to corroborate in vitro experiments and establish the mechanism...
[NMR paper] BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application.
BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application.
BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application.
ACS Med Chem Lett. 2020 May 14;11(5):883-888
Authors: Volpe SD, Listro R, Parafioriti M, Di Giacomo M, Rossi D, Ambrosio FA, Costa G, Alcaro S, Ortuso F, Hirsch AKH, Vasile F, Collina S
Abstract
The Hu family of RNA-binding proteins plays a crucial role in post-transcriptional processes;...
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[NMR paper] Beyond a fluorescent probe: Inhibition of cell division protein FtsZ by mant-GTP elucidated by NMR and biochemical approaches.
Beyond a fluorescent probe: Inhibition of cell division protein FtsZ by mant-GTP elucidated by NMR and biochemical approaches.
Related Articles Beyond a fluorescent probe: Inhibition of cell division protein FtsZ by mant-GTP elucidated by NMR and biochemical approaches.
ACS Chem Biol. 2015 Aug 6;
Authors: Huecas S, Marcelo F, Perona A, Ruiz LB, Morreale A, Cañada FJ, Jimenez-Barbero J, Andreu JM
Abstract
FtsZ is the organizer of cell division in most bacteria and a target in the quest for new antibiotics. FtsZ is a tubulin-like...
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08-08-2015 12:17 PM
[NMR paper] Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ.
Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ.
Related Articles Backbone and side chain NMR assignments of Geobacillus stearothermophilus ZapA allow identification of residues that mediate the interaction of ZapA with FtsZ.
Biomol NMR Assign. 2015 May 13;
Authors: Nogueira ML, Sforça ML, Chin YK, Mobli M, Handler A, Gorbatyuk VY, Robson SA, King GF, Gueiros-Filho FJ, Zeri AC
Abstract
Bacterial division begins with the...
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05-15-2015 08:02 PM
[NMR paper] Identification of palytoxin-Ca2+ complex by NMR and molecular modeling techniques.
Identification of palytoxin-Ca2+ complex by NMR and molecular modeling techniques.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Identification of palytoxin-Ca2+ complex by NMR and molecular modeling techniques.
J Org Chem. 2014 Jan 3;79(1):72-9
Authors: Ciminiello P, Dell'Aversano C, Dello Iacovo E, Forino M, Randazzo A, Tartaglione L
Abstract
More than 40 years after its isolation, the understanding of how palytoxin interacts with biological...
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08-30-2014 11:00 PM
[NMR paper] Backbone and side chain NMR assignments for the N-terminal domain of the cell division regulator MinC from Bacillus subtilis.
Backbone and side chain NMR assignments for the N-terminal domain of the cell division regulator MinC from Bacillus subtilis.
Related Articles Backbone and side chain NMR assignments for the N-terminal domain of the cell division regulator MinC from Bacillus subtilis.
Biomol NMR Assign. 2013 Dec 24;
Authors: Castellen P, Sforça ML, Gueiros-Filho FJ, de Mattos Zeri AC
Abstract
Bacterial cell division proteins must assemble at the middle of the cell to ensure the viability of both daughter cells. The first step in the assembly of the...
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12-25-2013 03:39 PM
[NMR paper] Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.
Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.
Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.
J Am Chem Soc. 2013 Sep 30;
Authors: Marcelo F, Huecas S, Ruiz-Avila LB, Cañada FJ, Perona A, Poveda A, Martin-Santamaria S, Morreale A, Jimenez-Barbero J, Andreu JM
Abstract
FtsZ is the key protein of...
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10-02-2013 11:18 AM
[NMR paper] Towards a structure for a TSG-6.hyaluronan complex by modeling and NMR spectroscopy:
Towards a structure for a TSG-6.hyaluronan complex by modeling and NMR spectroscopy: insights into other members of the link module superfamily.
Related Articles Towards a structure for a TSG-6.hyaluronan complex by modeling and NMR spectroscopy: insights into other members of the link module superfamily.
J Biol Chem. 2005 May 6;280(18):18189-201
Authors: Blundell CD, Almond A, Mahoney DJ, DeAngelis PL, Campbell ID, Day AJ
The Link module from human TSG-6, a hyaladherin with roles in ovulation and inflammation, has a hyaluronan (HA)-binding...
NMR study of the interaction between MinC and FtsZ and modeling of the FtsZ:MinC complex
Linear Mode
