Amyloid fibrils are insoluble, fibrous nanostructures that accumulate extracellularly in biological tissue during the progression of several human disorders, including Alzheimer's disease (AD) and type 2 diabetes. Fibrils are assembled from protein monomers via the transient formation of soluble, cytotoxic oligomers, and have a common molecular architecture consisting of a spinal core of hydrogen-bonded protein ?-strands. For the past 25 years, NMR spectroscopy has been at the forefront of...
[NMR paper] Exploring interactions between lipids and amyloid-forming proteins: a review for applying fluorescence and NMR techniques
Exploring interactions between lipids and amyloid-forming proteins: a review for applying fluorescence and NMR techniques
A hallmark of Alzheimer's, Parkinson's, and other amyloid diseases is the assembly of amyloid proteins into amyloid aggregates or fibrils. In many cases, the formation and cytotoxicity of amyloid assemblies are associated with their interaction with cell membranes. Despite studied for many years, the characterization of the interaction is challenged for reasons on the multiple aggregation states of amyloid-forming proteins, transient and weak interactions in the complex...
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[NMR paper] Exploring interactions between lipids and amyloid-forming proteins: a review for applying fluorescence and NMR techniques.
Exploring interactions between lipids and amyloid-forming proteins: a review for applying fluorescence and NMR techniques.
Related Articles Exploring interactions between lipids and amyloid-forming proteins: a review for applying fluorescence and NMR techniques.
Chem Phys Lipids. 2021 Feb 15;:105062
Authors: Chang Z, Deng J, Zhao W, Yang J
Abstract
A hallmark of Alzheimer's, Parkinson's, and other amyloid diseases is the assembly of amyloid proteins into amyloid aggregates or fibrils. In many cases, the formation and cytotoxicity...
[NMR paper] Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.
Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.
Related Articles Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.
Biochim Biophys Acta. 2017 Jun 06;:
Authors: Naito A, Matsumori N, Ramamoorthy A
Abstract
A variety of biomolecules acting on the cell membrane folds into a biologically active structure in the membrane environment. It is, therefore,...
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06-11-2017 06:00 PM
WaterDistribution, Dynamics, and Interactions withAlzheimer’s ?-Amyloid Fibrils Investigated bySolid-State NMR
WaterDistribution, Dynamics, and Interactions withAlzheimer’s ?-Amyloid Fibrils Investigated bySolid-State NMR
Tuo Wang, Hyunil Jo, William F. DeGrado and Mei Hong
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.7b02089/20170421/images/medium/ja-2017-02089e_0009.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.7b02089
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/UN3-dx0SQ1I
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04-22-2017 07:21 AM
[NMR paper] Water Distribution, Dynamics and Interactions with Alzheimer's ?-Amyloid Fibrils Investigated by Solid-State NMR.
Water Distribution, Dynamics and Interactions with Alzheimer's ?-Amyloid Fibrils Investigated by Solid-State NMR.
Water Distribution, Dynamics and Interactions with Alzheimer's ?-Amyloid Fibrils Investigated by Solid-State NMR.
J Am Chem Soc. 2017 Apr 13;:
Authors: Wang T, Jo H, DeGrado WF, Hong M
Abstract
Water is essential for protein folding and assembly of amyloid fibrils. Internal water cavities have been proposed for several amyloid fibrils, but no direct structural and dynamical data have been reported on the water...
Solid-state NMR of amyloid membrane interactions.
Solid-state NMR of amyloid membrane interactions.
Solid-state NMR of amyloid membrane interactions.
Methods Mol Biol. 2011;752:165-77
Authors: Gehman JD, Separovic F
Solid-state NMR pulse sequences often feature fewer pulses and delays than the more common solution NMR experiments. This ostensible simplicity, however, belies the care with which experimental parameters must be determined, as solid-state NMR can be much less forgiving of improper experimental set-up. This is especially true of "semi-solid" samples, such as the phospholipid vesicles...