The 106-residue protein Q4DY78 (UniProt accession number) from Trypanosoma cruzi is highly conserved in the related kinetoplastid pathogens Trypanosoma brucei and Leishmania major. Given the essentiality of its orthologue in T. brucei, the high sequence conservation with other trypanosomatid proteins, and the low sequence similarity with mammalian proteins, Q4DY78 is an attractive protein for structural characterization. Here, we solved the structure of Q4DY78 by solution NMR and evaluated its...
[NMR paper] An NMR biochemical assay for oxidosqualene cyclase: evaluation of inhibitor activities on Trypanosoma cruzi and human enzymes.
An NMR biochemical assay for oxidosqualene cyclase: evaluation of inhibitor activities on Trypanosoma cruzi and human enzymes.
Related Articles An NMR biochemical assay for oxidosqualene cyclase: evaluation of inhibitor activities on Trypanosoma cruzi and human enzymes.
J Med Chem. 2018 May 17;:
Authors: Tani O, Akutsu Y, Ito S, Suzuki T, Tateishi Y, Yamaguchi T, Niimi T, Namatame I, Chiba Y, Sakashita H, Kubota T, Yanagi T, Mizukami S, Hirayama K, Furukawa K, Yamasaki K
Abstract
Oxidosqualene cyclase (OSC), a membrane-associated...
nmrlearner
Journal club
0
05-18-2018 05:21 PM
[ASAP] Changes in Protein Dynamics in Escherichia coli SufS Reveal a Possible Conserved Regulatory Mechanism in Type II Cysteine Desulfurase Systems
Changes in Protein Dynamics in Escherichia coli SufS Reveal a Possible Conserved Regulatory Mechanism in Type II Cysteine Desulfurase Systems
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b01275/20180404/images/medium/bi-2017-012754_0008.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b01275
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/RiC9C-kPHns
More...
nmrlearner
Journal club
0
04-06-2018 01:51 AM
[NMR paper] NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi.
NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi.
Related Articles NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi.
J Struct Biol. 2015 Mar 4;
Authors: López-Castilla A, Pons T, Pires JR
Abstract
Q4D059 (UniProt accession number), is an 86-residue protein from Trypanosoma cruzi, conserved in the related kinetoplastid parasites Trypanosoma brucei and Leishmania major. These pathogens are the causal agents of the...
nmrlearner
Journal club
0
03-10-2015 07:22 PM
NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi
NMR structure and dynamics of Q4D059, a kinetoplastid-specific and conserved protein from Trypanosoma cruzi
Publication date: Available online 4 March 2015
Source:Journal of Structural Biology</br>
Author(s): Aracelys López-Castilla , Tirso Pons , José R. Pires</br>
Q4D059 (UniProt accession number), is an 86-residue protein from Trypanosoma cruzi, conserved in the related kinetoplastid parasites Trypanosoma brucei and Leishmania major. These pathogens are the causal agents of the neglected diseases: Chagas, sleeping sickness and leishmaniases respectively and had...
nmrlearner
Journal club
0
03-06-2015 12:45 AM
[NMR paper] NMR structure of the conserved hypothetical protein TM0979 from Thermotoga maritima.
NMR structure of the conserved hypothetical protein TM0979 from Thermotoga maritima.
Related Articles NMR structure of the conserved hypothetical protein TM0979 from Thermotoga maritima.
Proteins. 2005 May 1;59(2):387-90
Authors: Peti W, Herrmann T, Zagnitko O, Grzechnik SK, Wüthrich K
nmrlearner
Journal club
0
11-25-2010 08:21 PM
[NMR paper] NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: c
NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: contribution of a beta hairpin to RNA binding.
Related Articles NMR structural study of TcUBP1, a single RRM domain protein from Trypanosoma cruzi: contribution of a beta hairpin to RNA binding.
Biochemistry. 2005 Mar 15;44(10):3708-17
Authors: Volpon L, D'Orso I, Young CR, Frasch AC, Gehring K
TcUBP1 is a trypanosome cytoplasmic RNA-binding protein containing a single, conserved RNA-recognition motif (RRM) domain involved in selective destabilization of U-rich...
nmrlearner
Journal club
0
11-24-2010 11:14 PM
[NMR paper] NMR structure of conserved eukaryotic protein ZK652.3 from C. elegans: a ubiquitin-li
NMR structure of conserved eukaryotic protein ZK652.3 from C. elegans: a ubiquitin-like fold.
Related Articles NMR structure of conserved eukaryotic protein ZK652.3 from C. elegans: a ubiquitin-like fold.
Proteins. 2002 Sep 1;48(4):733-6
Authors: Cort JR, Chiang Y, Zheng D, Montelione GT, Kennedy MA
nmrlearner
Journal club
0
11-24-2010 08:58 PM
[NMR paper] NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacteriu
NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum.
Related Articles NMR-based structure of the conserved protein MTH865 from the archaeon Methanobacterium thermoautotrophicum.
J Biomol NMR. 2001 Sep;21(1):63-6
Authors: Lee GM, Edwards AM, Arrowsmith CH, McIntosh LP
NMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi
Linear Mode
