Metal-based drugs can modulate various biological processes and exhibit a rich variety of properties that foster their use in biomedicine and chemical biology. On the way to intracellular targets, ligand exchange and redox reactions can take place, thus making metallodrug speciation in vivo a challenging task. Advances in NMR spectroscopy have made it possible to move from solution to live-cell studies and elucidate the transport of metallodrugs and interactions with macromolecular targets in a...
[NMR paper] Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
Metab Brain Dis. 2018 10;33(5):1661-1668
Authors: Zhou Q, Zheng H, Chen J, Li C, Du Y, Xia H, Gao H
Abstract
Alzheimer's disease (AD) has been...
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05-09-2019 05:55 AM
How Common ALS Mutation Damages Cells and Leads to Toxic Protein Being Produced Detailed in Study - ALS News Today
How Common ALS Mutation Damages Cells and Leads to Toxic Protein Being Produced Detailed in Study - ALS News Today
How Common ALS Mutation Damages Cells and Leads to Toxic Protein Being Produced Detailed in Study ALS News TodayRepeat expansion in the C9orf72 gene, a known ALS mutation, was foun in a lab study to change the length of proteins called DPRs, turning them toxic.
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Interpretingthe Paramagnetic NMR Spectra of Potential Ru(III) Metallodrugs: Synergybetween Experiment and Relativistic DFT Calculations
Interpretingthe Paramagnetic NMR Spectra of Potential Ru(III) Metallodrugs: Synergybetween Experiment and Relativistic DFT Calculations
Jan Novotny?, Martin Sojka, Stanislav Komorovsky, Marek Nec?as and Radek Marek
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.6b02749/20160705/images/medium/ja-2016-02749g_0013.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.6b02749
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/QEEKosTvBHA
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[NMR paper] Fate of Pup inside the Mycobacterium Proteasome Studied by in-Cell NMR.
Fate of Pup inside the Mycobacterium Proteasome Studied by in-Cell NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png Related Articles Fate of Pup inside the Mycobacterium Proteasome Studied by in-Cell NMR.
PLoS One. 2013;8(9):e74576
Authors: Maldonado AY, Burz DS, Reverdatto S, Shekhtman A
Abstract
The Mycobacterium tuberculosis proteasome is required for maximum virulence and to resist killing by the host immune system. The prokaryotic ubiquitin-like protein, Pup-GGE,...
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09-17-2013 11:36 PM
[NMR paper] An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca(2+) concentration in HeLa cells.
An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca(2+) concentration in HeLa cells.
An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca(2+) concentration in HeLa cells.
Biochem Biophys Res Commun. 2013 Aug 7;
Authors: Hembram DS, Haremaki T, Hamatsu J, Inoue J, Kamoshida H, Ikeya T, Mishima M, Mikawa T, Hayashi N, Shirakawa M, Ito Y
Abstract
Recent developments in in-cell NMR techniques have allowed us to study proteins in detail inside living eukaryotic cells. The lifetime of in-cell NMR...
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STD and trNOESY NMR study of receptor-ligand interactions in living cancer cells.
STD and trNOESY NMR study of receptor-ligand interactions in living cancer cells.
STD and trNOESY NMR study of receptor-ligand interactions in living cancer cells.
Chembiochem. 2011 Mar 21;12(5):695-9
Authors: Potenza D, Vasile F, Belvisi L, Civera M, Araldi EM
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[NMR paper] Identification of Li(+) binding sites and the effect of Li(+) treatment on phospholipid composition in human neuroblastoma cells: a (7)Li and (31)P NMR study.
Identification of Li(+) binding sites and the effect of Li(+) treatment on phospholipid composition in human neuroblastoma cells: a (7)Li and (31)P NMR study.
Related Articles Identification of Li(+) binding sites and the effect of Li(+) treatment on phospholipid composition in human neuroblastoma cells: a (7)Li and (31)P NMR study.
Biochim Biophys Acta. 2005 Sep 25;1741(3):339-49
Authors: Layden BT, Abukhdeir AM, Malarkey C, Oriti LA, Salah W, Stigler C, Geraldes CF, Mota de Freitas D
Li(+) binding in subcellular fractions of human...
NMR spectroscopy to study the fate of metallodrugs in cells
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