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Default NMR signal loss of mutant lysozyme with pressure [Biological Sciences]

NMR signal loss of mutant lysozyme with pressure [Biological Sciences]

Kitahara, R., Mulder, F. A. A....
Date: 2015-03-03

In PNAS, Nucci et al. (1) present an NMR study suggesting the pressure-induced denaturation of individual domains of the T4 lysozyme mutant Leu99Ala (T4L L99A). The denaturation equilibrium was considered to be responsible for the pressure-induced loss of 15N-1H heteronuclear single quantum coherence (HSQC) cross-peaks, which were preferentially observed for... Read More


PNAS:
Number: 9
Volume: 112
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