Miro2 and Miro1 are mitochondrial-associated proteins critical for regulating mitochondrial movement within the cell. Both Miro1 and Miro2 have roles in promoting neuron function, but recently Miro2 has been shown to have additional roles in response to nutrient starvation in tumor cells. Miro1 and 2 consist of two small GTPase domains flanking a pair of EF-hands. The N-terminal GTPase (nGTPase) domain is responsible for initiating mitochondrial trafficking and interactions with GCN1 in prostate...
[NMR paper] NMR assignment of human HSP90 N-terminal domain bound to a long residence time resorcinol ligand
NMR assignment of human HSP90 N-terminal domain bound to a long residence time resorcinol ligand
HSP90 is a major molecular chaperone that helps both folding and stabilization of various client proteins often implicated in growth control and cell survival such as kinases and transcription factors. However, among HSP90 clients are also found numerous oncoproteins and, through its assistance to them, HSP90 has consequently been reported as a promising anticancer target. Several ligand chemotypes, including resorcinol type ligands, were found to inhibit HSP90, most of them in an ATP...
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[NMR paper] 1H, 13C, and 15N NMR chemical shift assignment of the complex formed by the first EPEC EspF repeat and N-WASP GTPase binding domain.
1H, 13C, and 15N NMR chemical shift assignment of the complex formed by the first EPEC EspF repeat and N-WASP GTPase binding domain.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles 1H, 13C, and 15N NMR chemical shift assignment of the complex formed by the first EPEC EspF repeat and N-WASP GTPase binding domain.
Biomol NMR Assign. 2021 Jan 21;:
Authors: Karjalainen M, Hellman M, Tossavainen H, Permi P
Abstract
LEE-encoded...
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[NMR paper] NMR resonance assignment and backbone dynamics of a C-terminal domain homolog of orange carotenoid protein.
NMR resonance assignment and backbone dynamics of a C-terminal domain homolog of orange carotenoid protein.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles NMR resonance assignment and backbone dynamics of a C-terminal domain homolog of orange carotenoid protein.
Biomol NMR Assign. 2020 Sep 16;:
Authors: Maksimov EG, Laptev GY, Blokhin DS, Klochkov VV, Slonimskiy YB, Sluchanko NN, Friedrich T, Chang CF, Polshakov VI
Abstract
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[NMR paper] NMR resonance assignment and structure prediction of the C-terminal domain of the microtubule end-binding protein 3.
NMR resonance assignment and structure prediction of the C-terminal domain of the microtubule end-binding protein 3.
Related Articles NMR resonance assignment and structure prediction of the C-terminal domain of the microtubule end-binding protein 3.
PLoS One. 2020;15(5):e0232338
Authors: Abdelkarim H, Hitchinson B, Qu X, Banerjee A, Komarova YA, Gaponenko V
Abstract
End-binding proteins (EBs) associate with the growing microtubule plus ends to regulate microtubule dynamics as well as the interaction with intracellular...
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[NMR paper] NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.
NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.
Related Articles NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.
Biomol NMR Assign. 2018 May 02;:
Authors: Sharma AK, Lee SJ, Rigby AC, Townson SA
Abstract
K-Ras is a key driver of oncogenesis, accounting for approximately 80% of Ras-driven human cancers. The small GTPase cycles between an inactive, GDP-bound and an active, GTP-bound state, regulated by...
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[NMR paper] Solution NMR assignment of the C-terminal domain of human chTOG.
Solution NMR assignment of the C-terminal domain of human chTOG.
Related Articles Solution NMR assignment of the C-terminal domain of human chTOG.
Biomol NMR Assign. 2018 Mar 26;:
Authors: Rostkova E, Burgess SG, Bayliss R, Pfuhl M
Abstract
The microtubule regulatory protein colonic and hepatic tumor overexpressed gene (chTOG), also known as cytoskeleleton associated protein 5 (CKAP5) plays an important role in organizing the cytoskeleton and in particular in the assembly of k-fibres in mitosis. Recently, we dissected the...
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[NMR paper] NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states.
NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states.
Biomol NMR Assign. 2015 Apr;9(1):201-5
Authors: Takeuchi K, Sun ZY, Li S, Gal M, Wagner G
Abstract
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NMR resonance assignment of the N-terminal GTPase domain of human Miro2 Bound to GTP
Linear Mode
