Metabolomic age models have been proposed for the study of biological aging, however, they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models for prediction of chronological age (CA), mortality, and age-related disease. Ninety-eight metabolic variables were measured in blood from nine UK and Finnish cohort studies (N ?31,000 individuals, age range 24-86 years). We used nonlinear...
[NMR paper] NMR metabolomic modelling of age and lifespan: a multi-cohort analysis
NMR metabolomic modelling of age and lifespan: a multi-cohort analysis
Metabolomic age models have been proposed for the study of biological aging, however they have not been widely validated. We aimed to assess the performance of newly developed and existing nuclear magnetic resonance spectroscopy (NMR) metabolomic age models for prediction of chronological age (CA), mortality, and age-related disease. 98 metabolic variables were measured in blood from nine UK and Finnish cohort studies (N ? 31,000 individuals, age range 24-86 years). We used non-linear and...
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11-21-2023 03:55 PM
[NMR paper] NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice
NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice
CONCLUSIONS: This study reveals the molecular mechanisms underlying the effects of moxibustion treatment on the skin lesions of psoriasis, potentially improving the clinical efficacy of moxibustion.
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Descriptive review of current NMR-based metabolomic data analysis packages
Descriptive review of current NMR-based metabolomic data analysis packages
Publication year: 2011
Source:Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 59, Issue 3</br>
Jose L. Izquierdo-García, Palmira Villa, Angelos Kyriazis, Laura del Puerto-Nevado, Sandra Pérez-Rial, Ignacio Rodriguez, Natalia Hernandez, Jesús Ruiz-Cabello</br>
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03-09-2012 09:16 AM
Use of optimized 1D TOCSY NMR for improved quantitation and metabolomic analysis of biofluids
Use of optimized 1D TOCSY NMR for improved quantitation and metabolomic analysis of biofluids
Abstract One dimensional selective TOCSY experiments have been shown to be advantageous in providing improved data inputs for principle component analysis (PCA) (Sandusky and Raftery 2005a, b). Better subpopulation cluster resolution in the observed scores plots results from the ability to isolate metabolite signals of interest via the TOCSY based filtering approach. This report reexamines the quantitative aspects of this approach, first by optimizing the 1D TOCSY experiment as it relates to...
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03-13-2011 05:24 AM
Descriptive Review of Current NMR-Based Metabolomic Data Analysis Packages
Descriptive Review of Current NMR-Based Metabolomic Data Analysis Packages
Publication year: 2011
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, In Press, Accepted Manuscript, Available online 21 February 2011</br>
Jose L., Izquierdo-García , Palmira, Villa , Angelos, Kyriazis , Laura del, Puerto-Nevado , Sandra, Pérez-Rial , ...</br>
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NMR metabolomic modeling of age and lifespan: A multicohort analysis
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