NMR Meets Tau: Insights into Its Function and Pathology.
Biomolecules. 2016;6(2)
Authors: Lippens G, Landrieu I, Smet C, Huvent I, Gandhi NS, Gigant B, Despres C, Qi H, Lopez J
Abstract
In this review, we focus on what we have learned from Nuclear Magnetic Resonance (NMR) studies on the neuronal microtubule-associated protein Tau. We consider both the mechanistic details of Tau: the tubulin relationship and its aggregation process. Phosphorylation of Tau is intimately linked to both aspects. NMR spectroscopy has depicted accurate phosphorylation patterns by different kinases, and its non-destructive character has allowed functional assays with the same samples. Finally, we will discuss other post-translational modifications of Tau and its interaction with other cellular factors in relationship to its (dys)function.
[NMR paper] The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights.
The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-highwire.gif Related Articles The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights.
Biochem J. 2015 Oct 15;471(2):155-65
Authors: Wen Y, Shi L, Ding Y, Cui R, He WT, Hu HY,...
nmrlearner
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01-01-2016 05:03 PM
Postdoctoral Research Associate in Pathology and Laboratory Medicine at UNC - Chapel Hill
This position, in the lab of David C Williams Jr, MD, PhD, will involve NMR analysis of the structure and dynamics of protein-DNA complexes. The work will include DNA cloning, isotopically labeled protein expression, and extensive NMR data collection and analysis.
Applicants should have a PhD degree in biological or chemical sciences plus experience with NMR spectroscopy and structure determination is required. Proficiency in DNA cloning and protein expression is expected.
Applicants should apply online at http://unc.peopleadmin.com/postings/42205 and attach a cover letter, curriculum...
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04-23-2014 01:46 PM
[NMR paper] Insights into hERG K+ channel structure and function from NMR studies.
Insights into hERG K+ channel structure and function from NMR studies.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles Insights into hERG K+ channel structure and function from NMR studies.
Eur Biophys J. 2013 Jan;42(1):71-9
Authors: Ng CA, Torres AM, Pagès G, Kuchel PW, Vandenberg JI
Abstract
The unique gating kinetics of hERG K(+) channels are critical for normal cardiac repolarization, and patients with mutations in hERG have a...
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06-15-2013 09:13 PM
Handheld cancer detection: Microfluidics meets NMR
Handheld cancer detection: Microfluidics meets NMR
http://www.spectroscopynow.com/common/images/thumbnails/13ef060ff6a.jpgA handheld device first developed for cancer diagnosis has been adapted to rapidly diagnose tuberculosis (TB) and other bacterial infections. Two papers appearing in the journals Nature Communications and Nature Nanotechnology describe the portable systems that bring together microfluidics technology and NMR.
Read the rest at Spectroscopynow.com
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General
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06-01-2013 02:03 PM
When detergent meets bilayer: birth and coming of age of lipid bicelles
When detergent meets bilayer: birth and coming of age of lipid bicelles
Available online 23 January 2013
Publication year: 2013
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
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Graphical abstract
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01-24-2013 09:57 AM
[NMRpipe Yahoo group] Re: MED function error.
Re: MED function error.
Hi Jason, Thanks very much for bringing this problem to my attention ... sorry, I (yes, even I) made what we call in the trade a "+ 1" "- 1" kind of mistake
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07-05-2012 04:13 AM
[NMRpipe Yahoo group] MED function error.
MED function error.
Dear Frank, We are experiencing segmentation faults in recent versions of NMRPipe on Mac OS X (10.6.8) when using the MED function. An example 2D processing
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07-04-2012 01:08 AM
[NMR analysis blog] Micropost [OT]: NMR meets Football
Micropost : NMR meets Football
http://2.bp.blogspot.com/_-MfflvAgRls/SwUfZ413_FI/AAAAAAAAAgk/SY9PjMIRoDQ/s400/NMRBalls.jpg
Relaxation plays a major role in NMR spectroscopy – What’s better than playing sports to chill out and forget about everyday problems?
I reckon this is not the best football team you might find but at least I guarantee they are fun people (sponsored by a great company :-) ) with whom you can have a good time (and get a free t-shirt!) :-)
Mestrelab World of Sports - Free Mnova t-shirt quiz
NMR Meets Tau: Insights into Its Function and Pathology.
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