Mitochondria form tubular networks that undergo coordinated cycles of fission and fusion. Emerging evidence suggests that a direct yet unresolved interaction of the mechanoenzymatic GTPase dynamin-related protein 1 (Drp1) with mitochondrial outer membrane-localized cardiolipin (CL), externalized under stress conditions including mitophagy, catalyzes essential mitochondrial hyperfragmentation. Here, using a comprehensive set of structural, biophysical, and cell biological tools, we have uncovered...
NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission [Biophysics and Computational Biology]
NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission
Mukesh Mahajan, Nikhil Bharambe, Yutong Shang, Bin Lu, Abhishek Mandal, Pooja Madan Mohan, Rihua Wang, Jennifer C. Boatz, Juan Manuel Martinez Galvez, Anna V. Shnyrova, Xin Qi, Matthias Buck, Patrick C. A. van der Wel, Rajesh Ramachandran...
Date: 2021-07-14
Mitochondria form tubular networks that undergo coordinated cycles of fission and fusion. Emerging evidence suggests that a direct yet unresolved interaction of the mechanoenzymatic GTPase dynamin-related protein 1...
nmrlearner
Journal club
0
07-14-2021 10:07 PM
[ASAP] Extratelomeric Binding of the Telomere Binding Protein TRF2 at the PCGF3 Promoter Is G-Quadruplex Motif-Dependent
Extratelomeric Binding of the Telomere Binding Protein TRF2 at the PCGF3 Promoter Is G-Quadruplex Motif-Dependent
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00019/20180410/images/medium/bi-2018-00019w_0005.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00019
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/kty9sAc251I
More...
nmrlearner
Journal club
0
04-12-2018 01:01 AM
Identification of a Conserved Histidine As Being Criticalfor the Catalytic Mechanism and Functional Switching of the MultifunctionalProline Utilization A Protein
Identification of a Conserved Histidine As Being Criticalfor the Catalytic Mechanism and Functional Switching of the MultifunctionalProline Utilization A Protein
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00046/20170608/images/medium/bi-2017-00046v_0008.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00046
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/QaVnb-Q_-nk
More...
[NMR paper] An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca(2+) concentration in HeLa cells.
An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca(2+) concentration in HeLa cells.
An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca(2+) concentration in HeLa cells.
Biochem Biophys Res Commun. 2013 Aug 7;
Authors: Hembram DS, Haremaki T, Hamatsu J, Inoue J, Kamoshida H, Ikeya T, Mishima M, Mikawa T, Hayashi N, Shirakawa M, Ito Y
Abstract
Recent developments in in-cell NMR techniques have allowed us to study proteins in detail inside living eukaryotic cells. The lifetime of in-cell NMR...
nmrlearner
Journal club
0
08-13-2013 04:26 PM
[NMR paper] NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
Related Articles NMR-based metabolomics of urine in a mouse model of Alzheimer's disease: identification of oxidative stress biomarkers.
J Clin Biochem Nutr. 2013 Mar;52(2):133-8
Authors: Fukuhara K, Ohno A, Ota Y, Senoo Y, Maekawa K, Okuda H, Kurihara M, Okuno A, Niida S, Saito Y, Takikawa O
Abstract
Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia among elderly patients. A biomarker...
nmrlearner
Journal club
0
03-26-2013 01:30 PM
[NMR paper] NMR identification of the Tom20 binding segment in mitochondrial presequences.
NMR identification of the Tom20 binding segment in mitochondrial presequences.
Related Articles NMR identification of the Tom20 binding segment in mitochondrial presequences.
J Mol Biol. 2001 Feb 16;306(2):137-43
Authors: Muto T, Obita T, Abe Y, Shodai T, Endo T, Kohda D
Many mitochondrial proteins are synthesized in the cytosol as precursors with N-terminal presequences, and are imported into mitochondria with the aid of translocator protein complexes containing presequence-binding proteins. Tom20, a receptor protein which functions in an...
nmrlearner
Journal club
0
11-19-2010 08:32 PM
[NMR paper] Essential dynamics from NMR clusters: dynamic properties of the Myb DNA-binding domai
Essential dynamics from NMR clusters: dynamic properties of the Myb DNA-binding domain and a hinge-bending enhancing variant.
Related Articles Essential dynamics from NMR clusters: dynamic properties of the Myb DNA-binding domain and a hinge-bending enhancing variant.
Methods. 1998 Mar;14(3):318-28
Authors: van Aalten DM, Grotewold E, Joshua-Tor L
Application of the "essential dynamics" method to the NMR cluster of structures for the R2R3 DNA-binding domain of the mouse c-Myb transcriptional activator is described. Using this method, large...
NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission
Linear Mode
