Bioavailability is a major bottleneck in the clinical application of medium molecular weight therapeutics, including protein and peptide drugs. Paracellular transport of these molecules is hampered by intercellular tight junction (TJ) complexes. Therefore, safe chemical regulators for TJ loosening are desired. Here, we showed a potential application of select non-steroidal anti-inflammatory drugs (NSAIDs) as TJ modulators. Based on our previous observation that diclofenac and flufenamic acid...
[NMR paper] [Anti-inflammatory mechanism of Crepis crocea based on NF-?B signaling pathway and ~1H-NMR metabonomics].
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Zhongguo Zhong Yao Za Zhi. 2020 Feb;45(4):946-954
Authors: Miao YL, He P, Zhang WX, Zhang WZ, Feng M, Ni Y
Abstract
Based on ~1H-NMR metabonomics technique and Western blot assay, the anti-inflammatory mechanism of Crepis crocea was discussed. In this study, male SD rats were treated with water extract(2.5 g·kg~(-1)) and dexamethasone acetate(6.25×10~(-4) g·kg~(-1)) for one week, and the inflammation model was induced by lipopolysaccharide(LPS). Then the counts of inflammatory cells white blood ceel(WBC),...
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[NMR paper] [Anti-inflammatory active fraction screening and mechanism of unripe Forsythiae Fructus based on ¹H-NMR metabolomics].
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Zhongguo Zhong Yao Za Zhi. 2016 Sep;41(18):3443-3450
Authors: Yue YH, He P, Sun YN, Bai GY, Hao XL, Ni Y
Abstract
To screen the anti-inflammatory active fraction of unripe Forsythiae Fructus, and elucidate the action mechanism, water decoction, ethyl acetate portion, n-butanol portion and residue water extracts of unripe Forsythiae Fructus were administered into rats for continuously 15 days. The acute lung injury inflammatory model was established to observe the section structure of lung tissues. Levels of...
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[ASAP] Single-Molecule Imaging Reveals Conformational Manipulation of Holliday Junction DNA by the Junction Processing Protein RuvA
Single-Molecule Imaging Reveals Conformational Manipulation of Holliday Junction DNA by the Junction Processing Protein RuvA
https://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.8b00404/20180524/images/medium/bi-2018-00404a_0006.gif
Biochemistry
DOI: 10.1021/acs.biochem.8b00404
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05-25-2018 12:07 PM
Interfering with enzyme's movement may be new approach for developing of anti-cancer drugs - News-Medical.net
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Interfering with enzyme's movement may be new approach for developing of anti-cancer drugs
News-Medical.net
To watch a kinase called mitogen-activated protein kinase (MAPK) p38 in action, the researchers used nuclear magnetic resonance (NMR) spectroscopy. All necessary molecules had to bind to p38 for the enzyme to become active. Only then could the ...
Interfering with enzyme's movement may be new...
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05-16-2018 03:42 PM
[NMR paper] Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles.
Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles.
J Am Chem Soc. 2016 Sep 21;138(37):12029-12032
Authors: Bayro MJ, Ganser-Pornillos BK, Zadrozny KK, Yeager M, Tycko R
Abstract
Maturation of...
Anti-malaria drugs could treat Parkinson's disease | TODAYonline - TODAYonline
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Anti-malaria drugs could treat Parkinson's disease | TODAYonline
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Associate Professor at the Nanyang Technological University (NTU) School of Biological Sciences Yoon Ho Sup with a protein sample, which will then be inserted into a Nuclear Magnetic Resonance (NMR) spectroscopy machine to identify the compounds ...
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Anti-malaria drugs could treat Parkinson's disease | TODAYonline -...
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07-17-2015 02:13 AM
Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G(*) apolipoprotein J peptide using solution NMR.
Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G(*) apolipoprotein J peptide using solution NMR.
Structure and lipid interactions of an anti-inflammatory and anti-atherogenic 10-residue class G(*) apolipoprotein J peptide using solution NMR.
Biochim Biophys Acta. 2011 Jan;1808(1):498-507
Authors: Mishra VK, Palgunachari MN, Hudson JS, Shin R, Keenum TD, Krishna NR, Anantharamaiah GM
The surprising observation that a 10-residue class G(?) peptide from apolipoprotein J, apoJ, possesses...
NMR-Guided Repositioning of Non-Steroidal Anti-Inflammatory Drugs into Tight Junction Modulators
Linear Mode
