NMR Dynamic View of the Stabilization of the WW4 Domain by Neutral NaCl and Kosmotropic Na(2)SO(4) and NaH(2)PO(4)
 

NMR Dynamic View of the Stabilization of the WW4 Domain by Neutral NaCl and Kosmotropic Na(2)SO(4) and NaH(2)PO(4)

The Hofmeister series categorizes ions based on their effects on protein stability, yet the microscopic mechanism remains a mystery. In this series, NaCl is neutral, Na(2)SO(4) and Na(2)HPO(4) are kosmotropic, while GdmCl and NaSCN are chaotropic. This study employs CD and NMR to investigate the effects of NaCl, Na(2)SO(4), and Na(2)HPO(4) on the conformation, stability, binding, and backbone dynamics (ps-ns and µs-ms time scales) of the WW4 domain with a high stability and accessible side...

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