Control of posttranscriptional mRNA decay is a crucial determinant of cell homeostasis and differentiation. mRNA lifetime is governed by cis-regulatory elements in their 3' untranslated regions (UTR). Despite ongoing progress in the identification of cis elements we have little knowledge about the functional and structural integration of multiple elements in 3'UTR regulatory hubs and their recognition by mRNA-binding proteins (RBPs). Structural analyses are complicated by inconsistent mapping...
1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution - DocWire News
1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution - DocWire News
1H, 13C and 15N resonance assignment of the SARS-CoV-2 full-length nsp1 protein and its mutants reveals its unique secondary structure features in solution DocWire News
NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment Wiley
Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2 News-Medical.Net
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[NMR paper] NMR structure of a full-length single-pass membrane protein NRADD.
NMR structure of a full-length single-pass membrane protein NRADD.
Related Articles NMR structure of a full-length single-pass membrane protein NRADD.
Proteins. 2019 Apr 29;:
Authors: Nadezhdin KD, Goncharuk SA, Arseniev AS, Mineev KS
Abstract
Structural study of any single-pass membrane protein is both an important and challenging task. In this report, we present the structure of a neurotrophin receptor-alike death-domain protein, NRADD. The structure and dynamics of the protein was investigated by conventional nuclear magnetic...
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04-30-2019 03:58 PM
[NMR paper] Solid-state NMR structure of a pathogenic fibril of full-length human ?-synuclein.
Solid-state NMR structure of a pathogenic fibril of full-length human ?-synuclein.
Related Articles Solid-state NMR structure of a pathogenic fibril of full-length human ?-synuclein.
Nat Struct Mol Biol. 2016 Mar 28;
Authors: Tuttle MD, Comellas G, Nieuwkoop AJ, Covell DJ, Berthold DA, Kloepper KD, Courtney JM, Kim JK, Barclay AM, Kendall A, Wan W, Stubbs G, Schwieters CD, Lee VM, George JM, Rienstra CM
Abstract
Misfolded ?-synuclein amyloid fibrils are the principal components of Lewy bodies and neurites, hallmarks of...
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NMR Analyses of the Structure and Dynamics of Klebsiella Pneumoniae OMPA Domains and Full Length Protein
NMR Analyses of the Structure and Dynamics of Klebsiella Pneumoniae OMPA Domains and Full Length Protein
Publication date: 28 January 2014
Source:Biophysical Journal, Volume 106, Issue 2, Supplement 1</br>
Author(s): Guillaume Nars , Iordan Iordanov , Marie Renault , Olivier Saurel , Pascal Demange , Alain Milon</br>
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[NMR paper] Mapping the binding site of full length HIV-1 Nef on human Lck SH3 by NMR spectroscop
Mapping the binding site of full length HIV-1 Nef on human Lck SH3 by NMR spectroscopy.
Related Articles Mapping the binding site of full length HIV-1 Nef on human Lck SH3 by NMR spectroscopy.
J Biomed Sci. 2005;12(3):451-6
Authors: Briese L, Preusser A, Willbold D
The Nef protein of human immunodeficiency virus type 1 (HIV-1) is known to directly bind to the SH3 domain of human lymphocyte specific kinase (Lck) via a proline-rich region located in the amino terminal part of Nef. To address the question whether Nef binding to Lck SH3 involves...
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[NMR paper] NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop bin
NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein.
Related Articles NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein.
RNA. 2002 Jan;8(1):83-96
Authors: DeJong ES, Marzluff WF, Nikonowicz EP
The 3' end of replication-dependent histone mRNAs terminate in a conserved sequence containing a stem-loop. This 26-nt sequence is the binding site for a protein, stem-loop binding protein (SLBP), that is involved in multiple aspects of histone mRNA metabolism...
NMR-derived secondary structure of the full-length Ox40 mRNA 3'UTR and its multivalent binding to the immunoregulatory RBP Roquin
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