Related ArticlesNMR-Based Serum Metabolomics Discriminates Takayasu Arteritis from Healthy Individuals: A Proof-of-Principle Study.
J Proteome Res. 2015 Aug 7;14(8):3372-81
Authors: Guleria A, Misra DP, Rawat A, Dubey D, Khetrapal CL, Bacon P, Misra R, Kumar D
Abstract
Takayasu arteritis (TA) is a debilitating, systemic disease that involves the aorta and large arteries in a chronic inflammatory process that leads to vessel stenosis. Initially, the disease remains clinically silent (or remains undetected) until the patients present with vascular occlusion. Therefore, new methods for appropriate and timely diagnosis of TA cases are needed to start proper therapy on time and also to monitor the patient's response to the given treatment. In this context, NMR-based serum metabolomic profiling has been explored in this proof-of-principle study for the first time to determine characteristic metabolites that could be potentially helpful for diagnosis and prognosis of TA. Serum metabolic profiling of TA patients (n = 29) and healthy controls (n = 30) was performed using 1D (1)H NMR spectroscopy, and possible biomarker metabolites were identified. Using projection to least-squares discriminant analysis, we could distinguish TA patients from healthy controls. Compared to healthy controls, TA patients had (a) increased serum levels of choline metabolites, LDL cholesterol, N-acetyl glycoproteins (NAGs), and glucose and (b) decreased serum levels of lactate, lipids, HDL cholesterol, and glucogenic amino acids. The results of this study are preliminary and need to be confirmed in a prospective study.
[NMR paper] ¹H-NMR and MS based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet.
¹H-NMR and MS based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles ¹H-NMR and MS based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet.
PLoS One. 2015;10(3):e0120950
Authors: Li...
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[NMR paper] (1)H NMR-based metabolomics study on the physiological variations during the rat pregnancy process.
(1)H NMR-based metabolomics study on the physiological variations during the rat pregnancy process.
(1)H NMR-based metabolomics study on the physiological variations during the rat pregnancy process.
Mol Cell Endocrinol. 2016 Jan 7;
Authors: Shen G, Li Z, Zhang Y, Wu H, Feng J
Abstract
In this study, NMR-based metabolomics in combination with multivariate pattern recognition technologies were employed to evaluate the physiological variations in the Wistar rats' plasma that are induced by pregnancy on the gestational days (GDs)...
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01-17-2016 12:06 PM
[NMR paper] 1H-NMR-Based Metabolomic Study for Identifying Serum Profiles Associated with the Response to Etanercept in Patients with Rheumatoid Arthritis.
1H-NMR-Based Metabolomic Study for Identifying Serum Profiles Associated with the Response to Etanercept in Patients with Rheumatoid Arthritis.
1H-NMR-Based Metabolomic Study for Identifying Serum Profiles Associated with the Response to Etanercept in Patients with Rheumatoid Arthritis.
PLoS One. 2015;10(11):e0138537
Authors: Priori R, Casadei L, Valerio M, Scrivo R, Valesini G, Manetti C
Abstract
OBJECTIVE: A considerable proportion of patients with rheumatoid arthritis (RA) do not have a satisfactory response to biological...
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11-13-2015 11:33 AM
[NMR paper] (1)H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus).
(1)H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus).
(1)H NMR based metabolomics approach to study the toxic effects of dichlorvos on goldfish (Carassius auratus).
Chemosphere. 2015 Jul 22;138:537-545
Authors: Liu Y, Chen T, Li MH, Xu HD, Jia AQ, Zhang JF, Wang JS
Abstract
Dichlorvos (DDVP), one of the most widely used organophosphorus pesticides (OPs), has caused serious pollution in environment. In this study, (1)H nuclear magnetic resonance (NMR) based metabolomics...
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07-27-2015 10:16 AM
[NMR paper] Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine.
J Proteome Res. 2014 Dec 22;
Authors: Pinto J, Barros AS, Domingues MR, Goodfellow BJ, Galhano E, Pita C, Almeida MD, Carreira IM, Gil AM
Abstract
This paper presents the first NMR metabolomics study of maternal plasma during pregnancy, including correlation between plasma and urine metabolites. The expected decrease in circulating amino acids early in pregnancy...
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12-23-2014 12:58 PM
[NMR paper] An NMR-based metabolomics study of pork from different crossbreeds and relation to sensory perception.
An NMR-based metabolomics study of pork from different crossbreeds and relation to sensory perception.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles An NMR-based metabolomics study of pork from different crossbreeds and relation to sensory perception.
Meat Sci. 2014 Feb;96(2 Pt A):719-28
Authors: Straadt IK, Aaslyng MD, Bertram HC
Abstract
Meat extracts from five different pig crossbreeds including Duroc/Landrace/Yorkshire (DLY),...
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07-30-2014 10:22 AM
[NMR paper] Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy...