Related ArticlesNMR-based metabonomic analysis of physiological responses to starvation and refeeding in the rat.
J Proteome Res. 2016 Aug 12;
Authors: Serrano-Contreras JI, Garcia-Perez I, Meléndez-Camargo ME, Zepeda LG
Abstract
Starvation is a postabsorptive condition derived from a limitation on food resources by external factors. Energy homeostasis is maintained under this condition by using sources other than glucose via adaptive mechanisms. After refeeding, when food is available, other adaptive processes are linked to energy balance. However, less has been reported about the physiological mechanisms present as a result of these conditions, considering the rat as a supraorganism. Metabolic profiling by nuclear magnetic resonance spectroscopy was used to elucidate the physiological metabolic differences in urine specimens collected under starved, refed and recovered conditions. In addition, since starvation induced lack of faecal production and not all animals produced faeces during refeeding, 24-h pooled faecal water samples were also analysed. Urinary metabolites upregulated by starvation included 2-butanamidoacetate, 3-hydroxyisovalerate, ketoleucine, methylmalonate, p-cresyl glucuronide, p-cresyl sulfate, phenylacetylglycine, pseudouridine, creatinine, taurine and N-acetyl glycoprotein, which were related to renal and skeletal muscle function, ?-oxidation, turnover of proteins and RNA, and host-microbial interactions. Food-derived metabolites, including gut microbial co-metabolites, and tricarboxylic acid cycle intermediates were upregulated under refed and recovered conditions, which characterised anabolic urinary metabotypes. The upregulation of creatine and pantothenate indicated an absorptive state after refeeding. Fecal short chain fatty acids, 3-(3-hydroxyphenyl)propionate, lactate and acetoin provided additional information about the combinatorial metabolism between the host and gut microbiota. This investigation contributes to allow a deeper understanding of physiological responses associated with starvation and refeeding.
PMID: 27518853 [PubMed - as supplied by publisher]
[NMR paper] (1)HNMR-based metabonomic study of sub-chronic hepatotoxicity induced by realgar.
(1)HNMR-based metabonomic study of sub-chronic hepatotoxicity induced by realgar.
(1)HNMR-based metabonomic study of sub-chronic hepatotoxicity induced by realgar.
J Ethnopharmacol. 2016 Jul 1;
Authors: Huo T, Fang Y, Zhao L, Xiong Z, Zhang Y, Wang Y, Feng C, Yuan M, Wang S, Chen M, Jiang H
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Realgar has been used as a traditional Chinese medicine (TCM) for thousands of years. Recently, a number of realgar or realgar-containing medicines poisoning cases have been reported. However, the...
nmrlearner
Journal club
0
07-06-2016 03:13 PM
[NMR paper] (1)H NMR-based metabolomics study on the physiological variations during the rat pregnancy process.
(1)H NMR-based metabolomics study on the physiological variations during the rat pregnancy process.
(1)H NMR-based metabolomics study on the physiological variations during the rat pregnancy process.
Mol Cell Endocrinol. 2016 Jan 7;
Authors: Shen G, Li Z, Zhang Y, Wu H, Feng J
Abstract
In this study, NMR-based metabolomics in combination with multivariate pattern recognition technologies were employed to evaluate the physiological variations in the Wistar rats' plasma that are induced by pregnancy on the gestational days (GDs)...
nmrlearner
Journal club
0
01-17-2016 12:06 PM
[NMR paper] Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy.
Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.rsc.org-images-entities-char_z_RSClogo.gif Related Articles Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy.
Mol Biosyst. 2014 Dec;10(12):3170-8
Authors: Yang Y, Liu Y, Zheng L, Wu T, Li J, Zhang Q, Li X, Yuan F, Wang L, Guo J
Abstract
Atherosclerosis is a multifactorial...
nmrlearner
Journal club
0
08-15-2015 04:01 PM
[NMR paper] Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Systemic and characteristic metabolites in the serum of streptozotocin-induced diabetic rats at different stages as revealed by a (1)H-NMR based metabonomic approach.
Mol Biosyst. 2014 Jan 21;
Authors: Diao C, Zhao L, Guan M, Zheng Y, Chen M, Yang Y, Lin L, Chen W, Gao H
Abstract
Diabetes mellitus is a typical heterogeneous metabolic disorder characterized by abnormal...
nmrlearner
Journal club
0
01-23-2014 03:58 PM
[NMR paper] 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 1H NMR-based metabonomic analysis of the serum and urine of rats following subchronic exposure to dichlorvos, deltamethrin, or a combination of these two pesticides.
Chem Biol Interact. 2013 May 25;203(3):588-96
Authors: Wang HP, Liang YJ, Sun YJ, Chen JX,...
nmrlearner
Journal club
0
07-17-2013 12:00 PM
[NMR paper] Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Advantage of Applying OSC to (1)H NMR-Based Metabonomic Data of Celiac Disease.
Int J Endocrinol Metab. 2012;10(3):548-552
Authors: Rezaei-Tavirani M, Fathi F, Darvizeh F, Zali MR, Rostami Nejad M, Rostami K, Tafazzoli M, Arefi Oskouie A, Mortazavi-Tabatabaei SA
Abstract
BACKGROUND: Celiac disease (CD) is a disorder associated with body reaction to gluten. After the gluten intake, an immune reaction against the protein occurs and damages villi of small...
nmrlearner
Journal club
0
07-12-2013 06:01 PM
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.
J Nutr Biochem. 2011 Mar 21;
Authors: He Q, Ren P, Kong X, Wu Y, Wu G, Li P, Hao F, Tang H, Blachier F, Yin Y
Childhood obesity has become a prevalent risk to health of children and teenagers. To develop biomarkers in serum for altered lipid metabolism, genetically obese (Ningxiang strain) and lean...
nmrlearner
Journal club
0
03-25-2011 06:34 PM
NMR-based metabonomic investigation of heat stress in myotubes reveals a time-depende
NMR-based metabonomic investigation of heat stress in myotubes reveals a time-dependent change in the metabolites.
Related Articles NMR-based metabonomic investigation of heat stress in myotubes reveals a time-dependent change in the metabolites.
J Agric Food Chem. 2010 May 26;58(10):6376-86
Authors: Straadt IK, Young JF, Bross P, Gregersen N, Oksbjerg N, Theil PK, Bertram HC
NMR-based metabonomics was applied to elucidate the time-dependent stress responses in mouse myotubes after heat exposure of either 42 or 45 degrees C for 1 h. Principal...
NMR-based metabonomic analysis of physiological responses to starvation and refeeding in the rat.
Linear Mode
