Related ArticlesNMR-based identification of the major bioactive molecules from an Italian cultivar of Lycium barbarum.
Phytochemistry. 2017 Dec;144:52-57
Authors: Lopatriello A, Previtera R, Pace S, Werner M, Rubino L, Werz O, Taglialatela-Scafati O, Forino M
Abstract
Lycium barbarum (Solanaceae), long known to the traditional Chinese medicine because of its many health-promoting effects, has of late spread widely across the Western hemisphere, mainly on account of the nutritional richness in vitamins, minerals and antioxidant metabolites of its fruits. Data on bioactive metabolites from fruits and leaves, which are commonly consumed in soups and salads, are scarce and sometimes even contradictory. By means of NMR, the present study identified the specialised products contained in an Italian cultivar of L.*barbarum. Kaempeferol, caffeic acid, 3,4,5-trihydroxycinnamic acid and 5-hydroxyferulic acid were found in fresh fruits; rutin and chlorogenic acid were detected in leaves and flowers; also, a previously undescribed N,N-dicaffeoylspermidine derivative was identified in flowers, while N-feruloyltyramine derivatives, for which interesting anti-inflammatory properties have been reported, turned out to be the major bioactive molecules in stems. The plethora of the detected bioactive molecules amplifies the nutraceutical value of berries and leaves and prompts the exploitation of L.*barbarum flowers and pruned stems as sources of beneficial compounds.
[NMR paper] NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
Related Articles NMR-Based Strategies to Elucidate Bioactive Conformations of Weakly Binding Ligands.
Top Curr Chem. 2008;273:1-14
Authors: Blommers MJ, Strauss A, Geiser M, Ramage P, Sparrer H, Jahnke W
Abstract
Key processes in molecular biology are regulated by interactions between biomolecules. Protein-proteinand protein-ligand interactions, e.g., in signal transduction pathways, rely on the subtle interactionsbetween atoms at the binding interface of...
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04-24-2013 09:48 PM
First solid-state NMR analysis of uniformly (13)C-enriched major light-harvesting complexes from Chlamydomonas reinhardtti and identification of protein and cofactor spin clusters.
First solid-state NMR analysis of uniformly (13)C-enriched major light-harvesting complexes from Chlamydomonas reinhardtti and identification of protein and cofactor spin clusters.
First solid-state NMR analysis of uniformly (13)C-enriched major light-harvesting complexes from Chlamydomonas reinhardtti and identification of protein and cofactor spin clusters.
Biochim Biophys Acta. 2011 Jan 25;
Authors: Pandit A, Morosinotto T, Reus M, Holzwarth AR, Bassi R, de Groot HJ
The light-harvesting complex II (LHCII) is the main component of the...
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02-02-2011 02:40 AM
[NMR paper] NMR-based techniques in the hit identification and optimisation processes.
NMR-based techniques in the hit identification and optimisation processes.
Related Articles NMR-based techniques in the hit identification and optimisation processes.
Expert Opin Ther Targets. 2004 Dec;8(6):597-611
Authors: Pellecchia M, Becattini B, Crowell KJ, Fattorusso R, Forino M, Fragai M, Jung D, Mustelin T, Tautz L
In this review, the use of general NMR spectroscopy techniques to detect ligand binding and to monitor enzyme kinetics and inhibition, which appear particularly useful in hit identification and validation, is reiterated....
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11-24-2010 10:03 PM
[Stan NMR blog] MyMRs - a GPS of Italian NMR
MyMRs - a GPS of Italian NMR
A Google map with markers for various NMR instruments in Italy: call for input
Source: Stan blog library
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11-23-2010 07:10 AM
[NMR paper] Privileged molecules for protein binding identified from NMR-based screening.
Privileged molecules for protein binding identified from NMR-based screening.
Related Articles Privileged molecules for protein binding identified from NMR-based screening.
J Med Chem. 2000 Sep 7;43(18):3443-7
Authors: Hajduk PJ, Bures M, Praestgaard J, Fesik SW
A statistical analysis of NMR-derived binding data on 11 protein targets was performed to identify molecular motifs that are preferred for protein binding. The analysis indicates that compounds which contain a biphenyl substructure preferentially bind to a wide range of proteins and...
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11-19-2010 08:29 PM
Simultaneous de Novo Identification of Molecules in Chemical Mixtures by Doubly Indir
Simultaneous de Novo Identification of Molecules in Chemical Mixtures by Doubly Indirect Covariance NMR Spectroscopy
Fengli Zhang, Lei Bruschweiler-Li and Rafael Bru?schweiler
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja106781r/aop/images/medium/ja-2010-06781r_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/ja106781r
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/q3oWBh6znmg
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11-17-2010 06:08 PM
[Stan NMR blog] MyMRs - a GPS of Italian NMR
MyMRs - a GPS of Italian NMR
A Google map with markers for various NMR instruments in Italy: call for input
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