Abstract
Williams-Beuren syndrome is a genetic disorder characterized by physiological and mental abnormalities, and is caused by hemizygous deletion of several genes in chromosome 7. One of the removed genes encodes the WBSCR27 protein. Bioinformatic analysis of the sequence of WBSCR27 indicates that it belongs to the family of SAM-dependent methyltransferases. However, exact cellular functions of this protein or phenotypic consequences of its deficiency are still unknown. Here we report nearly complete 1H, 15N, and 13C chemical shifts assignments of the 26*kDa WBSCR27 protein from Mus musculus in complex with the cofactor S-adenosyl-L-methionine (SAM). Analysis of the assigned chemical shifts allowed us to characterize the protein's secondary structure and backbone dynamics. The topology of the protein's fold confirms the assumption that the WBSCR27 protein belongs to the family of class I methyltransferases.
PMID: 29868988 [PubMed - as supplied by publisher]
[NMR paper] NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV).
NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV).
NMR assignments of the macro domain from Middle East respiratory syndrome coronavirus (MERS-CoV).
Biomol NMR Assign. 2016 Mar 18;
Authors: Huang YP, Cho CC, Chang CF, Hsu CH
Abstract
The newly emerging human pathogen, Middle East respiratory syndrome coronavirus (MERS-CoV), contains a macro domain in the highly conserved N-terminal region of non-structural protein 3. Intense research has shown that macro domains bind ADP-ribose and...
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03-20-2016 10:51 AM
A Novel Inhibitor of the Obesity-Related Protein FTO
A Novel Inhibitor of the Obesity-Related Protein FTO
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.6b00023/20160304/images/medium/bi-2016-00023r_0009.gif
Biochemistry
DOI: 10.1021/acs.biochem.6b00023
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/B3hf_VejST0
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03-05-2016 11:21 AM
[NMR paper] NMR-based urinalysis for rapid diagnosis of ?-ureidopropionase deficiency in a patient with Dravet syndrome.
NMR-based urinalysis for rapid diagnosis of ?-ureidopropionase deficiency in a patient with Dravet syndrome.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR-based urinalysis for rapid diagnosis of ?-ureidopropionase deficiency in a patient with Dravet syndrome.
Clin Chim Acta. 2015 Feb 2;440:201-4
Authors: Lam CW, Law CY, Leung KF, Lai CK, Pak-lam Chen S, Chan B, Chan KY, Yuen YP, Mak CM, Yan-wo Chan A
Abstract
BACKGROUND:...
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10-06-2015 10:39 PM
[NMR paper] A pilot metabolic profiling study in hepatopancreas of Litopenaeus vannamei with white spot syndrome virus based on (1)H NMR spectroscopy.
A pilot metabolic profiling study in hepatopancreas of Litopenaeus vannamei with white spot syndrome virus based on (1)H NMR spectroscopy.
A pilot metabolic profiling study in hepatopancreas of Litopenaeus vannamei with white spot syndrome virus based on (1)H NMR spectroscopy.
J Invertebr Pathol. 2014 Oct 14;124C:51-56
Authors: Liu PF, Liu QH, Wu Y, Jie H
Abstract
White spot syndrome virus, which was a pathogen first found in 1992, had emerged globally affecting shrimp populations in aquaculture. Here, we comprehensively...
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12-03-2014 04:05 PM
[NMR paper] An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome.
An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome.
Related Articles An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome.
Biochim Biophys Acta. 2013 Mar 5;
Authors: Gravel AE, Arnold AA, Dufourc EJ, Marcotte I
Abstract
The human ether-a-go-go-related gene (hERG) voltage-gated K+ channels are located in heart cell membranes and hold a unique selectivity filter (SF) amino acid sequence (SVGFG) as compared...
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03-12-2013 07:09 PM
[NMR paper] MR spectroscopy in 18q(-) syndrome suggesting other than hypomyelination.
MR spectroscopy in 18q(-) syndrome suggesting other than hypomyelination.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles MR spectroscopy in 18q(-) syndrome suggesting other than hypomyelination.
Brain Dev. 2013 Jan 16;
Authors: Tada H, Takanashi JI
Abstract
We reported a 5-year-old boy with 18q(-) syndrome who showed typical magnetic resonance imaging (MRI) findings of high signal intensity on T2-weighted imaging, and a slightly high but lower than normal signal...
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02-03-2013 10:19 AM
NMR structure of the Bordetella bronchiseptica protein NP_888769.1 establishes a new phage-related protein family PF13554.
NMR structure of the Bordetella bronchiseptica protein NP_888769.1 establishes a new phage-related protein family PF13554.
NMR structure of the Bordetella bronchiseptica protein NP_888769.1 establishes a new phage-related protein family PF13554.
Protein Sci. 2011 Apr 21;
Authors: Atia-Tul-Wahab , Serrano P, Geralt M, Wüthrich K
The solution structure of the hypothetical phage-related protein NP_888769.1 from the gram-negative bacterium Bordetella bronchoseptica contains a well-structured core comprising a five-stranded, antiparallel ?-sheet packed...
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04-27-2011 04:03 PM
[NMR paper] NMR assignments of the winged-helix domain of human werner syndrome protein.
NMR assignments of the winged-helix domain of human werner syndrome protein.
Related Articles NMR assignments of the winged-helix domain of human werner syndrome protein.
J Biomol NMR. 2005 Jul;32(3):261
Authors: Sun JZ, Feng HQ, Lin GX, Zeng W, Hu JS
NMR assignments of the WBSCR27 protein related to Williams-Beuren syndrome.
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