The development of effective therapies as well as early, molecular diagnosis of Alzheimer's disease is impeded by the lack of understanding of the underlying pathological mechanisms. Metabolomics studies of body fluids as well as brain tissues have shown major changes in metabolic profiles of Alzheimer's patients. However, with analysis performed at the late stages of the disease it is not possible to distinguish causes and consequence. The mouse model APP/PS1 expresses a mutant amyloid...
[NMR paper] Metabolic changes in mice cardiac tissue after low-dose irradiation revealed by 1H NMR spectroscopy.
Metabolic changes in mice cardiac tissue after low-dose irradiation revealed by 1H NMR spectroscopy.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--academic.oup.com-images-oup_pubmed.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.ncbi.nlm.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.png Related Articles Metabolic changes in mice cardiac tissue after low-dose irradiation revealed by 1H NMR spectroscopy.
J Radiat Res. 2020 Jan 23;61(1):14-26
Authors: Gramatyka M, Boguszewicz ?, Ciszek M, Gabry? D,...
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10-11-2020 03:25 AM
[NMR paper] Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
Metab Brain Dis. 2018 10;33(5):1661-1668
Authors: Zhou Q, Zheng H, Chen J, Li C, Du Y, Xia H, Gao H
Abstract
Alzheimer's disease (AD) has been...
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05-09-2019 05:55 AM
Magic angle spinning NMR below 6 K with a computational fluid dynamics analysis of fluid flow and temperature gradients
From The DNP-NMR Blog:
Magic angle spinning NMR below 6 K with a computational fluid dynamics analysis of fluid flow and temperature gradients
This article is not specifically about DNP spectroscopy. However, magic angle spinning at 6K is definitely of interest to DNP, especially when using low-power, solid-state microwave sources.
Sesti, E.L., et al., Magic angle spinning NMR below 6 K with a computational fluid dynamics analysis of fluid flow and temperature gradients. J. Magn. Reson., 2018. 286(Supplement C): p. 1-9.
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01-17-2018 07:00 PM
[NMR paper] Whole Blood Reveals More Metabolic Detail of the Human Metabolome than Serum as Measured by 1H-NMR Spectroscopy: Implications for Sepsis Metabolomics.
Whole Blood Reveals More Metabolic Detail of the Human Metabolome than Serum as Measured by 1H-NMR Spectroscopy: Implications for Sepsis Metabolomics.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pt.wkhealth.com-pt-pt-core-template-journal-lwwgateway-images-pmlogoPubMed.jpg Related Articles Whole Blood Reveals More Metabolic Detail of the Human Metabolome than Serum as Measured by 1H-NMR Spectroscopy: Implications for Sepsis Metabolomics.
Shock. 2015 Sep;44(3):200-8
Authors: Stringer KA, Younger JG, McHugh C, Yeomans L,...
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05-03-2016 01:13 PM
[NMR paper] (1)H- and (13)C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
(1)H- and (13)C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
Related Articles (1)H- and (13)C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
J Neural Transm. 2015 Mar 6;
Authors: Doert A, Pilatus U, Zanella F, Müller WE, Eckert GP
Abstract
Biochemical alterations underlying the symptoms and pathomechanisms of Alzheimer's disease (AD) are not fully understood. However, alterations of glucose metabolism and...
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03-08-2015 01:07 AM
Mice may hold the key to stopping Alzheimer's-like diseases - HealthCanal.com
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Mice may hold the key to stopping Alzheimer's-like diseases
HealthCanal.com
The study used Nuclear Magnetic Resonance spectroscopy to look at a molecular level at the interactions of the different proteins and identified tiny differences in the physical and chemical properties of the surfaces that made a great difference to ...
Mice may hold the key to stopping Alzheimer's-like diseases - HealthCanal.com
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Metabolic profiling of vitamin C deficiency in Guloâ??/â?? mice using proton NMR spectroscopy
Metabolic profiling of vitamin C deficiency in Guloâ??/â?? mice using proton NMR spectroscopy
Abstract Nutrient deficiencies are an ongoing problem in many populations and ascorbic acid is a key vitamin whose mild or acute absence leads to a number of conditions including the famously debilitating scurvy. As such, the biochemical effects of ascorbate deficiency merit ongoing scrutiny, and the Gulo knockout mouse provides a useful model for the metabolomic examination of vitamin C deficiency. Like humans, these animals are incapable of synthesizing ascorbic acid but with dietary...
NMR analysis of the correlation of metabolic changes in blood and cerebrospinal fluid in Alzheimer model male and female mice
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