NmrA homologs have been reported as conserved regulators of the nitrogen metabolite repression (NMR) in various fungi. Here, we identified a NmrA homolog in Verticillium dahliae and reported its functions in nitrogen utilization, growth and development, and pathogenesis. VdNmrA interacts with V. dahliae AreA protein and regulates the expression of a typical NCR target, the formamidase gene. VdNmrA deletion mutants exhibited significantly slower colony growth on media with Gln or Arg....
[NMR paper] Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy.
Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-elsevieroa.png Related Articles Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy.
Bioorg Med Chem. 2017 May 15;25(10):2730-2742
Authors: Fernandez...
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[NMR paper] Functional Analysis of the Nitrogen Metabolite Repression Regulator Gene nmrA in Aspergillus flavus.
Functional Analysis of the Nitrogen Metabolite Repression Regulator Gene nmrA in Aspergillus flavus.
Related Articles Functional Analysis of the Nitrogen Metabolite Repression Regulator Gene nmrA in Aspergillus flavus.
Front Microbiol. 2016;7:1794
Authors: Han X, Qiu M, Wang B, Yin WB, Nie X, Qin Q, Ren S, Yang K, Zhang F, Zhuang Z, Wang S
Abstract
In Aspergillus nidulans, the nitrogen metabolite repression (NMR) regulator NmrA plays a major role in regulating the activity of the GATA transcription factor AreA during nitrogen...
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[NMR paper] An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor.
An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor.
Related Articles An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor.
Molecules. 2016;21(7)
Authors: Khattri RB, Morris DL, Davis CM, Bilinovich SM, Caras AJ, Panzner MJ, Debord MA, Leeper TC
Abstract
Selective hits for the glutaredoxin ortholog of Brucella melitensis are determined using STD NMR and verified by trNOE and (15)N-HSQC titration. The most promising hit, RK207, was...
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[NMR paper] NMR study of histidine metabolism during alcoholic and malolactic fermentations of wine and their influence on histamine production.
NMR study of histidine metabolism during alcoholic and malolactic fermentations of wine and their influence on histamine production.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles NMR study of histidine metabolism during alcoholic and malolactic fermentations of wine and their influence on histamine production.
J Agric Food Chem. 2013 Oct 2;61(39):9464-9
Authors: López-Rituerto E, Avenoza A, Busto JH, Peregrina JM
Abstract
The metabolic pathways...
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1H NMR Probefor in Situ Monitoring ofDopamine Metabolism and Its Application to Inhibitor Screening
1H NMR Probefor in Situ Monitoring ofDopamine Metabolism and Its Application to Inhibitor Screening
Ryosuke Ueki, Koya Yamaguchi, Hiroshi Nonaka and Shinsuke Sando
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja305051u/aop/images/medium/ja-2012-05051u_0003.gif
Journal of the American Chemical Society
DOI: 10.1021/ja305051u
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/cexCOJvC3z0
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Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enymes for selective 15N-labelling and production of perdeuterated proteins in H2O
Suppression of isotope scrambling in cell-free protein synthesis by broadband inhibition of PLP enymes for selective 15N-labelling and production of perdeuterated proteins in H2O
Abstract Selectively isotope labelled protein samples can be prepared in vivo or in vitro from selectively labelled amino acids but, in many cases, metabolic conversions between different amino acids result in isotope scrambling. The best results are obtained by cell-free protein synthesis, where metabolic enzymes are generally less active, but isotope scrambling can never be suppressed completely. We show that...
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[NMR paper] Nitrogen-15 NMR studies of nitrogen metabolism in Picea glauca buds.
Nitrogen-15 NMR studies of nitrogen metabolism in Picea glauca buds.
Related Articles Nitrogen-15 NMR studies of nitrogen metabolism in Picea glauca buds.
Plant Physiol Biochem. 2004 Dec;42(10):803-9
Authors: Bagh K, Hiraoki T, Thorpe TA, Vogel HJ
In vivo (15)N nuclear magnetic resonance (NMR) as well as (15)N solid-state magic angle spinning (MAS) NMR spectroscopy were used to investigate nitrogen metabolism in cultured white spruce (Picea glauca) buds. Long-term as well as short-term experiments were carried out involving the use of...
A nitrogen-metabolism inhibitor NmrA regulates conidial production, melanin synthesis and virulence in phytopathogenic fungus Verticillium dahliae
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