We have developed the stochastic microscopic-order-macroscopic-disorder (MOMD) approach for elucidating dynamic structures in the solid-state from ²H NMR lineshapes. In MOMD, the probe experiences an effective/collective motional mode. The latter is described by a potential, u, which represents the local spatial-restrictions, a local-motional diffusion tensor, R, and key features of local geometry. Previously we applied MOMD to the well-structured core domain of the 3-fold-symmetric twisted...
[NMR paper] MOMD Analysis of NMR Lineshapes from A?-Amyloid Fibrils: A New Tool for Characterizing Molecular Environments in Protein Aggregates.
MOMD Analysis of NMR Lineshapes from A?-Amyloid Fibrils: A New Tool for Characterizing Molecular Environments in Protein Aggregates.
MOMD Analysis of NMR Lineshapes from A?-Amyloid Fibrils: A New Tool for Characterizing Molecular Environments in Protein Aggregates.
J Phys Chem B. 2018 Apr 06;:
Authors: Meirovitch E, Liang Z, Freed JH
Abstract
The microscopic-order-macroscopic-disorder (MOMD) approach for 2H NMR lineshape analysis is applied to dry and hydrated 3-fold-, and 2-fold-symmetric amyloid-A?40 fibrils, and protofibrils...
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04-07-2018 03:55 PM
[NMR paper] Protein dynamics in the solid-state from 2H NMR lineshape analysis. III. MOMD in the presence of Magic Angle Spinning.
Protein dynamics in the solid-state from 2H NMR lineshape analysis. III. MOMD in the presence of Magic Angle Spinning.
Related Articles Protein dynamics in the solid-state from 2H NMR lineshape analysis. III. MOMD in the presence of Magic Angle Spinning.
Solid State Nucl Magn Reson. 2017 Nov 21;:
Authors: Meirovitch E, Liang Z, Freed JH
Abstract
We report on a new approach to the analysis of dynamic NMR lineshapes from polycrystalline (i.e., macroscopically disordered) samples in the presence of Magic Angle Spinning (MAS). This...
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12-07-2017 11:34 AM
Protein dynamics in the solid-state from 2H NMR lineshape analysis. III. MOMD in the presence of Magic Angle Spinning
Protein dynamics in the solid-state from 2H NMR lineshape analysis. III. MOMD in the presence of Magic Angle Spinning
Publication date: Available online 21 November 2017
Source:Solid State Nuclear Magnetic Resonance</br>
Author(s): Eva Meirovitch, Zhichun Liang, Jack H. Freed</br>
We report on a new approach to the analysis of dynamic NMR lineshapes from polycrystalline (i.e., macroscopically disordered) samples in the presence of Magic Angle Spinning (MAS). This is an application of the Stochastic Liouville Equation developed by Freed and co-workers for...
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11-21-2017 10:10 PM
[NMR paper] Protein Dynamics in the Solid-State from 2H NMR Lineshape Analysis. II: MOMD Applied to C-D, and C-CD3 Probes.
Protein Dynamics in the Solid-State from 2H NMR Lineshape Analysis. II: MOMD Applied to C-D, and C-CD3 Probes.
Related Articles Protein Dynamics in the Solid-State from 2H NMR Lineshape Analysis. II: MOMD Applied to C-D, and C-CD3 Probes.
J Phys Chem B. 2015 Sep 24;
Authors: Meirovitch E, Liang Z, Freed JH
Abstract
Deuterium lineshape analysis from mobile C?-D and C-?CD3 groups has emerged as a particularly useful tool for studying dynamics in the solid-state. The theoretical models devised so far consist typically of sets...
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09-26-2015 05:13 AM
[NMR paper] Proteins Dynamics in the Solid-state from (2)H NMR Lineshape Analysis: a Consistent Perspective.
Proteins Dynamics in the Solid-state from (2)H NMR Lineshape Analysis: a Consistent Perspective.
Related Articles Proteins Dynamics in the Solid-state from (2)H NMR Lineshape Analysis: a Consistent Perspective.
J Phys Chem B. 2015 Jan 16;
Authors: Meirovitch E, Liang Z, Freed JH
Abstract
Deuterium lineshape analysis of CD3 groups emerged as a particularly useful tool for studying ?s - ms protein motions in the solid-state. The models devised so far consist of several independently conceived simple jump-type motions. They are...
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01-17-2015 04:14 PM
Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy
From The DNP-NMR Blog:
Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy
Debelouchina, G.T., et al., Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy. J Am Chem Soc, 2013. 135(51): p. 19237-47.
http://www.ncbi.nlm.nih.gov/pubmed/24304221
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01-27-2014 09:59 PM
HigherOrder Amyloid Fibril Structure by MAS NMR andDNP Spectroscopy
HigherOrder Amyloid Fibril Structure by MAS NMR andDNP Spectroscopy
Galia T. Debelouchina, Marvin J. Bayro, Anthony W. Fitzpatrick, Vladimir Ladizhansky, Michael T. Colvin, Marc A. Caporini, Christopher P. Jaroniec, Vikram S. Bajaj, Melanie Rosay, Cait E. MacPhee, Michele Vendruscolo, Werner E. Maas, Christopher M. Dobson and Robert G. Griffin
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja409050a/aop/images/medium/ja-2013-09050a_0011.gif
Journal of the American Chemical Society
DOI: 10.1021/ja409050a...
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12-14-2013 03:11 AM
[NMR paper] Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy.
Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy.
Related Articles Higher Order Amyloid Fibril Structure by MAS NMR and DNP Spectroscopy.
J Am Chem Soc. 2013 Dec 4;
Authors: Debelouchina GT, Bayro MJ, Fitzpatrick AW, Ladizhansky V, Colvin MT, Caporini MA, Jaroniec CP, Bajaj VS, Rosay MM, Macphee CE, Vendruscolo M, Maas WE, Dobson CM, Griffin RG
Abstract
Protein magic angle spinning (MAS) NMR spectroscopy has generated structural models of several amyloid fibril systems, thus providing valuable information regarding the...
The N-Terminal Domain of Abeta(40)-Amyloid Fibril: The MOMD Perspective of its Dynamic Structure from NMR Lineshape Analysis
Linear Mode
