[NMR paper] Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling
Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling
All cells are decorated with a highly dense and complex structure of glycan chains, which are mostly attached to proteins and lipids. In this context, sialic acids are a family of nine-carbon acidic monosaccharides typically found at the terminal position of glycan chains, modulating several physiological and pathological processes. Sialic acids have many structural and modulatory roles due to their negative charge and hydrophilicity. In addition, the recognition of sialic...
nmrlearner
Journal club
0
12-06-2021 11:12 PM
[NMR paper] NMR structure of the Vibrio vulnificus ribosomal protein S1 domains D3 and D4 provides insights into molecular recognition of single-stranded RNAs
NMR structure of the Vibrio vulnificus ribosomal protein S1 domains D3 and D4 provides insights into molecular recognition of single-stranded RNAs
The ribosomal S1 protein (rS1) is indispensable for translation initiation in Gram-negative bacteria. rS1 is a multidomain protein that acts as an RNA chaperone and ensures that mRNAs can bind the ribosome in a single-stranded conformation, which could be related to fast recognition. Although many ribosome structures were solved in recent years, a high-resolution structure of a two-domain mRNA-binding competent rS1 construct is not yet...
nmrlearner
Journal club
0
07-08-2021 11:44 AM
[NMR paper] Effects of Pectin Molecular Weight Changes on the Structure, Dynamics, and Polysaccharide Interactions of Primary Cell Walls of Arabidopsis thaliana: Insights from Solid-State NMR.
Effects of Pectin Molecular Weight Changes on the Structure, Dynamics, and Polysaccharide Interactions of Primary Cell Walls of Arabidopsis thaliana: Insights from Solid-State NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Effects of Pectin Molecular Weight Changes on the Structure, Dynamics, and Polysaccharide Interactions of Primary Cell Walls of Arabidopsis thaliana: Insights from Solid-State NMR.
Biomacromolecules. 2017 Sep 11;18(9):2937-2950
Authors: Phyo P,...
nmrlearner
Journal club
0
05-04-2018 03:33 PM
[NMR paper] The recognition of glycans by protein receptors. Insights from NMR spectroscopy.
The recognition of glycans by protein receptors. Insights from NMR spectroscopy.
Related Articles The recognition of glycans by protein receptors. Insights from NMR spectroscopy.
Chem Commun (Camb). 2018 Apr 17;:
Authors: Ardá A, Jiménez-Barbero J
Abstract
Carbohydrates (glycans, saccharides, sugars) are everywhere. In fact, glycan-protein interactions are involved in many essential processes of life and disease. The understanding of the key structural details at the atomic and molecular level is of paramount importance to...
nmrlearner
Journal club
0
04-18-2018 01:41 PM
[NMR paper] Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy.
Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy.
Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy.
Solid State Nucl Magn Reson. 2017 Oct 04;88:1-14
Authors: van der Wel PCA
Abstract
The aggregation of proteins and peptides into a variety of insoluble, and often non-native, aggregated states plays a central role in many devastating diseases. Analogous processes undermine the efficacy of polypeptide-based biological pharmaceuticals, but are also...
nmrlearner
Journal club
0
10-17-2017 10:19 AM
Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy
Insights into protein misfolding and aggregation enabled by solid-state NMR spectroscopy
Publication date: Available online 4 October 2017
Source:Solid State Nuclear Magnetic Resonance</br>
Author(s): Patrick C.A. van der Wel</br>
The aggregation of proteins and peptides into a variety of insoluble, and often non-native, aggregated states plays a central role in many devastating diseases. Analogous processes undermine the efficacy of polypeptide-based biological pharmaceuticals, but are also being leveraged in the design of biologically inspired self-assembling...
nmrlearner
Journal club
0
10-05-2017 07:28 PM
[NMR paper] Antigenic peptide recognition on the human ABC transporter TAP resolved by DNP-enhanced solid-state NMR spectroscopy.
Antigenic peptide recognition on the human ABC transporter TAP resolved by DNP-enhanced solid-state NMR spectroscopy.
Related Articles Antigenic peptide recognition on the human ABC transporter TAP resolved by DNP-enhanced solid-state NMR spectroscopy.
J Am Chem Soc. 2016 Sep 23;
Authors: Lehnert E, Mao J, Mehdipour AR, Hummer G, Abele R, Glaubitz C, Tampé R
Abstract
The human transporter associated with antigen processing (TAP) is a 140-kDa heterodimeric ABC transport complex, which selects peptides for export into the...
nmrlearner
Journal club
0
09-24-2016 05:20 PM
[NMR paper] Solid-State NMR in Macromolecular Systems: Insights on How Molecular Entities Move.
Solid-State NMR in Macromolecular Systems: Insights on How Molecular Entities Move.
Related Articles Solid-State NMR in Macromolecular Systems: Insights on How Molecular Entities Move.
Acc Chem Res. 2013 Mar 13;
Authors: Hansen MR, Graf R, Spiess HW
Abstract
The function of synthetic and natural macromolecularsystems critically depends on the packing and dynamics of the individual components of a given system. Not only can solid-state NMR provide structural information with atomic resolution, but it can also provide a way to characterize...
Molecular Recognition in Mechanochemistry: Insights from Solid-State NMR Spectroscopy
Linear Mode
