Molecular Interactions of Lipopolysaccharide withan Outer Membrane Protein from Pseudomonas aeruginosa Probed by Solution NMR
Molecular Interactions of Lipopolysaccharide withan Outer Membrane Protein from Pseudomonas aeruginosa Probed by Solution NMR
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Biochemistry
DOI: 10.1021/acs.biochem.6b00630
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Understanding the dynamics of protein-ligand interactions, which lie at the heart of host-pathogen recognition,...
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[NMR paper] Molecular Interactions of Lipopolysaccharide with an Outer Membrane Protein from Pseudomonas aeruginosa Probed by Solution NMR.
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Pseudomonas aeruginosa is an opportunistic human pathogen causing pneumonias that are particularly severe in cystic fibrosis and immunocompromised patients. The outer membrane (OM) of P....
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Biologically active organic molecules characterized by a high single bond torsional barrier generate isolable isomers (atropisomers) and offer a unique stereochemical component to the design of selective...
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FtsZ is the key protein of...
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Diseases that result from infection are, in general, a consequence of specific interactions between a pathogenic organism and the cells. The study of host-pathogen interactions has provided insights for the design of...
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It has been proposed that AlF4- can serve as a tetrahedral pseudophosphate bound to guanosine diphosphate (GDP) in G-protein systems. In a previous paper , 19F and 1H NMR were used to...
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With magnesium present, fluoride and aluminum ions activate heterotrimeric G-proteins by forming AlFx complexes that mimic the gamma phosphate of...