Related ArticlesMolecular Determinants of Chronic Liver Disease as Studied by NMR-Metabolomics.
Curr Top Med Chem. 2017 Jul 07;:
Authors: Embade N, Millet O
Abstract
Chronic liver diseases are one of the major causes of mortality worldwide. It can manifest through many different forms including chronic virus infection, alcohol abuse, metabolic syndromes such as non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. At early stages, the liver can repair the damage produced by the insult. However, upon continuous damage, the accumulation of molecules triggers fibrosis, which subsequently progresses towards cirrhosis and, ultimately, hepatocarcinoma. Early diagnosis of liver disease and a proper staging of fibrosis are crucial in therapy since drugs are only effective at incipient and intermediate stages of the disease. In this context, liver biopsy is the gold standard, but it is invasive and can produce complications. Metabolomics has emerged as a potent discipline to identify new biomarkers in a non-invasive way. Here, we compile and critically review the existing NMR-based metabolomics studies on chronic liver diseases, specifically covering non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, alcoholic liver disease and those produced by virus infection.
PMID: 28685692 [PubMed - as supplied by publisher]
[NMR paper] Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats.
Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.rsc.org-images-entities-char_z_RSClogo.gif Related Articles Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats.
Food Funct. 2015 Apr;6(4):1090-7
Authors: Moazzami AA, Frank S, Gombert A, Sus N, Bayram B, Rimbach G, Frank J
Abstract
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[NMR paper] NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats.
NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.rsc.org-images-entities-char_z_RSClogo.gif Related Articles NMR-based metabolomics approach to study the chronic toxicity of crude ricin from castor bean kernels on rats.
Mol Biosyst. 2014 Jul 29;10(9):2426-40
Authors: Guo P, Wang J, Dong G, Wei D, Li M, Yang M, Kong L
Abstract
Ricin, a large, water soluble toxic glycoprotein, is distributed...
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10-16-2015 01:44 PM
[NMR paper] Metabolomics analysis of cervical cancer, cervical intraepithelial neoplasia and chronic cervicitis by 1H NMR spectroscopy.
Metabolomics analysis of cervical cancer, cervical intraepithelial neoplasia and chronic cervicitis by 1H NMR spectroscopy.
Related Articles Metabolomics analysis of cervical cancer, cervical intraepithelial neoplasia and chronic cervicitis by 1H NMR spectroscopy.
Eur J Gynaecol Oncol. 2015;36(2):174-80
Authors: Ye N, Liu C, Shi P
Abstract
Metabolomics profiles of serum samples from women with chronic cervicitis, cervical intraepithelial neoplasia (CIN), and cervical cancer were characterized by proton nuclear magnetic resonance...
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08-19-2015 03:24 PM
[NMR paper] (1)H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease.
(1)H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease.
(1)H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease.
PLoS One. 2014 Jan 20;9(1):e85445
Authors: Kim JA, Choi HJ, Kwon YK, Ryu do H, Kwon TH, Hwang GS
Abstract
Chronic kidney disease (CKD) is characterized by the gradual loss of the kidney function to excrete wastes and fluids from the blood. (1)H NMR-based metabolomics was exploited to investigate the altered metabolic pattern in rats with CKD induced by surgical...
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[NMR paper] Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy individuals.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Metabonomic profiling of serum and urine by (1)H NMR-based spectroscopy discriminates patients with chronic obstructive pulmonary disease and healthy...
[NMR paper] NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T1 AM treatment.
NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T1 AM treatment.
Related Articles NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T1 AM treatment.
Obesity (Silver Spring). 2013 Mar 20;
Authors: Haviland JA, Reiland H, Butz DE, Tonelli M, Porter WP, Zucchi R, Scanlan TS, Chiellini G, Assadi-Porter FM
Abstract
OBJECTIVE: 3-iodothyronamine (T1 AM), an analog of thyroid hormone,is a recently discovered fast-acting endogenous metabolite. High...
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03-21-2013 02:58 PM
Nobel Laureate Presents Chronic Wasting Disease Lecture at UW - University of Wyoming
Nobel Laureate Presents Chronic Wasting Disease Lecture at UW - University of Wyoming News
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University of Wyoming News
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Nobel Laureate Presents Chronic Wasting Disease Lecture at UW
University of Wyoming News
His research interests include molecular structural biology, protein science and structural genomics with an emphasis on using nuclear magnetic resonance ...
Molecular Determinants of Chronic Liver Disease as Studied by NMR-Metabolomics.
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