[NMR paper] Modulation of the Oxygenation State and Intracellular pH of Erythrocytes by Inositol-Trispyrophosphate Investigated by (31)P NMR Study of 2,3-DPG
The hypoxic microenvironment is crucial for tumour cell growth and invasiveness. Tumour tissue results from adaptation to reduced oxygen availability. Hypoxia first activates pro-angiogenic signals for alleviation. Pathologic, tumour angiogenesis maintains hypoxia, impairing treatment outcomes. Vessel normalisation requires physioxia. Oxygen delivery by red blood cell (RBC) carrying haemoglobin (Hb) is enhanced by myo-inositol trispyrophosphate (ITPP), an effector of oxygen transport by RBCs....
[NMR paper] Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS.
Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS.
Related Articles Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS.
Cell Rep. 2020 Aug 25;32(8):108074
Authors: Zhao Q, Fujimiya R, Kubo S, Marshall CB, Ikura M, Shimada I, Nishida N
Abstract
The small guanosine triphosphatase (GTPase) RAS serves as a molecular switch in signal transduction, and its mutation and aberrant activation are implicated in tumorigenesis. Here, we perform real-time, in-cell nuclear...
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08-28-2020 02:27 PM
Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase
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Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase
p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Moure, M.J., et al., Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase. Chemical Communications, 2017. 53(92): p. 12398-12401.
http://dx.doi.org/10.1039/C7CC07023C
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01-27-2018 12:19 AM
Interaction of Human Chloride Intracellular ChannelProtein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study
Interaction of Human Chloride Intracellular ChannelProtein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.6b00080/20160628/images/medium/bi-2016-00080v_0005.gif
Biochemistry
DOI: 10.1021/acs.biochem.6b00080
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/4YjlGPTKTzA
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06-30-2016 02:26 AM
NMR structural study of the intracellular loop 3 of the serotonin 5-HT(1A) receptor and its interaction with calmodulin.
NMR structural study of the intracellular loop 3 of the serotonin 5-HT(1A) receptor and its interaction with calmodulin.
NMR structural study of the intracellular loop 3 of the serotonin 5-HT(1A) receptor and its interaction with calmodulin.
Biochim Biophys Acta. 2011 May 24;
Authors: Chen AS, Kim YM, Gayen S, Huang Q, Raida M, Kang C
The serotonin (5-HT(1A)) receptor, a G-protein-coupled receptor (GPCR), plays important roles in serotonergic signaling in the central nervous system. The third intracellular loop (ICL3) of the 5-HT(1A) receptor has...
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06-07-2011 11:05 AM
[NMR paper] 7Li NMR relaxation study of Li+ binding in human erythrocytes.
7Li NMR relaxation study of Li+ binding in human erythrocytes.
Related Articles 7Li NMR relaxation study of Li+ binding in human erythrocytes.
Biochemistry. 1993 Dec 14;32(49):13490-8
Authors: Rong Q, Espanol M, Mota de Freitas D, Geraldes CF
We used 7Li NMR spin-lattice (T1) and spin-spin (T2) relaxation time measurements to investigate the binding of Li+ in human red blood cell (RBC) suspensions. In RBCs containing 1.4 mM Li+, the intracellular 7Li NMR T2 relaxation value (0.30 +/- 0.03 s) was much smaller than the corresponding T1 value...
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08-22-2010 03:01 AM
[NMR paper] 19F-NMR study of the effect of lead on intracellular free calcium in human platelets.
19F-NMR study of the effect of lead on intracellular free calcium in human platelets.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles 19F-NMR study of the effect of lead on intracellular free calcium in human platelets.
Biochim Biophys Acta. 1991 May 17;1092(3):341-6
Authors: Dowd TL, Gupta RK
Lead has been shown to affect calcium homeostasis. However, there is no prior evidence to indicate an effect of low concentrations of lead in the environment (approximately 1...
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08-21-2010 11:16 PM
[NMR paper] Study on the erythrocytes from myotonic dystrophy with multi-nuclear NMR.
Study on the erythrocytes from myotonic dystrophy with multi-nuclear NMR.
Related Articles Study on the erythrocytes from myotonic dystrophy with multi-nuclear NMR.
Muscle Nerve. 1991 Jan;14(1):57-63
Authors: Kuwabara T, Yuasa T, Ohno T, Yamamuro M, Miyatake T
We have studied the water permeability through membranes, the function of the Na pump, and glucose metabolism of erythrocytes of patients with myotonic muscular dystrophy (MyD) using 1H--, 23Na, and 13C-NMR techniques. A significant decrease in water permeability was recognized in the...
Modulation of the Oxygenation State and Intracellular pH of Erythrocytes by Inositol-Trispyrophosphate Investigated by (31)P NMR Study of 2,3-DPG
Linear Mode
