MOBI: a web server to define and visualize structural mobility in NMR protein ensembl
 

MOBI: a web server to define and visualize structural mobility in NMR protein ensembles.

Related Articles MOBI: a web server to define and visualize structural mobility in NMR protein ensembles.

Bioinformatics. 2010 Sep 21;

Authors: Martin AJ, Walsh I, Tosatto SC

MOTIVATION: MOBI is a web server for the identification of structurally mobile regions in NMR protein ensembles. It provides a binary mobility definition that is analogous to the commonly used definition of intrinsic disorder in X-ray crystallographic structures. At least three different use cases can be envisaged: (i) Visualization of NMR mobility for structural analysis; (ii) definition of regions for reliable comparative modelling in protein structure prediction; (iii) definition of mobility in analogy to intrinsic disorder. MOBI uses structural superposition and local conformation differences to derive a robust binary mobility definition that is in excellent agreement with the manually curated definition used in the CASP8 experiment for intrinsic disorder in NMR structure. The output includes mobility-coloured PDB files, mobility plots and a FASTA formatted sequence file summarizing the mobility results. AVAILABILITY: The MOBI server and supplementary methods are available for non-commercial use at URL: http://protein.bio.unipd.it/mobi/.

PMID: 20861031 [PubMed - as supplied by publisher]



Source: PubMed