Structure determination lies at the heart of many biochemical research programs. However, the 'giants,' X-ray diffraction, electron microscopy, molecular dynamics simulations, and nuclear magnetic resonance (NMR), among others, leave quite a few dark spots on the structural pictures drawn of proteins, nucleic acids, membranes, and other biomacromolecules. For example, structural models under physiological conditions or of short-lived intermediates often remain out of reach of the established...
Protein Science by DNA Sequencing: How Advances in Molecular Biology Are Accelerating Biochemistry
Protein Science by DNA Sequencing: How Advances in Molecular Biology Are Accelerating Biochemistry
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00886/20171020/images/medium/bi-2017-008868_0004.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00886
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[NMR paper] NMR structure of bitistatin – a missing piece in the evolutionary pathway of snake venom disintegrins.
NMR structure of bitistatin – a missing piece in the evolutionary pathway of snake venom disintegrins.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary_FullTextOnline_120x27.gif Related Articles NMR structure of bitistatin – a missing piece in the evolutionary pathway of snake venom disintegrins.
FEBS J. 2015 Jan;282(2):341-60
Authors: Carbajo RJ, Sanz L, Perez A, Calvete JJ
Abstract
Extant disintegrins, as found in the venoms of Viperidae and...
[NMR paper] NMR solution structure of complement-like repeat CR3 from the low density lipoprotein
NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.
Related Articles NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.
J Biol Chem. 2000 Feb 4;275(5):3264-9
Authors: Dolmer K, Huang W, Gettins PG
We have used NMR methods to determine the...
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[NMR paper] NMR solution structure of complement-like repeat CR8 from the low density lipoprotein
NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-standard-jbc_full_free.gif Related Articles NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein.
J Biol Chem. 1999 May 14;274(20):14130-6
Authors: Huang W, Dolmer K, Gettins PG
The low density lipoprotein receptor-related protein is a member of the low density...
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08-21-2010 04:03 PM
Postdoctoral positions in Biochemistry and Structural Biology
Postdoctoral positions in Biochemistry and Structural Biology
Two postdoc positions are currently available in the laboratory of Dr. Jamil Saad at the University of Alabama at Birmingham (UAB).
Our research program is aimed at understanding the precise molecular mechanism of how retroviral proteins interact with cellular factors during the virus replication cycle. We use a set of biochemical, biophysical and structural biology (mainly NMR and occasionally X-ray) tools to characterize key protein-protein and protein-lipid interactions critical for vi…
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