Related ArticlesMetabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
Metab Brain Dis. 2018 10;33(5):1661-1668
Authors: Zhou Q, Zheng H, Chen J, Li C, Du Y, Xia H, Gao H
Abstract
Alzheimer's disease (AD) has been associated with the disturbance of brain glucose metabolism. The present study investigates brain glucose metabolism using 13C NMR metabolomics in combination with intravenous [1-13C]-glucose infusion in APP/PS1 transgenic mouse model of amyloid pathology at 10*months of age. We found that brain glucose was significantly accumulated in APP/PS1 mice relative to wild-type (WT) mice. Reductions in 13C fluxes into the specific carbon sites of tricarboxylic acid (TCA) intermediate (succinate) as well as neurotransmitters (glutamate, glutamine, ?-aminobutyric acid and aspartate) from [1-13C]-glucose were also detected in the brain of APP/PS1 mice. In addition, our results reveal that the 13C-enrichments of the C3 of alanine were significantly lower and the C3 of lactate have a tendency to be lower in the brain of APP/PS1 mice than WT mice. Taken together, the development of amyloid pathology could cause a reduction in glucose utilization and further result in decreases in energy and neurotransmitter metabolism as well as the lactate-alanine shuttle in the brain.
[NMR paper] (1)H- and (13)C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
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Authors: Doert A, Pilatus U, Zanella F, Müller WE, Eckert GP
Abstract
Biochemical alterations underlying the symptoms and pathomechanisms of Alzheimer's disease (AD) are not fully understood. However, alterations of glucose metabolism and...
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[NMR paper] 1H NMR metabolomic signatures in five brain regions of the A?PPswe Tg2576 mouse model of Alzheimer's disease at four ages.
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http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--iospress.metapress.com-images-ios-pubmed.gif Related Articles 1H NMR metabolomic signatures in five brain regions of the A?PPswe Tg2576 mouse model of Alzheimer's disease at four ages.
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Authors: Lalande J, Halley H, Balayssac S, Gilard V, Déjean S, Martino R, Francés B, Lassalle JM, Malet-Martino M
Abstract
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http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Gender-specific metabolomic profiling of obesity in leptin-deficient ob/ob mice by 1H NMR spectroscopy.
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Abstract
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http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.nature.com-images-lo_tp.gif Related Articles Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.
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J Physiol Biochem. 2013 Jan 19;
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Abstract
Metabolomics is a high-throughput tool...
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Metabolic fate of glucose in the brain of APP/PS1 transgenic mice at 10*months of age: a 13C NMR metabolomic study.
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