Role of the Interdomain Linker in RNA-Activated ProteinKinase Activation
Role of the Interdomain Linker in RNA-Activated ProteinKinase Activation
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.5b01171/20151230/images/medium/bi-2015-01171g_0008.gif
Biochemistry
DOI: 10.1021/acs.biochem.5b01171
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12-31-2015 12:34 PM
Zinc deficiency:Hedgehog activation
Zinc deficiency:Hedgehog activation
http://www.spectroscopynow.com/common/images/thumbnails/14d04207a5f.jpgZinc deficiency, which is associated with various cancers, can lead to activation of the "Hedgehog" signalling pathway, according to evidence arising from studies that involved solution NMR spectroscopy.
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05-01-2015 01:34 PM
[NMR paper] Conformational Ensembles in GPCR Activation.
Conformational Ensembles in GPCR Activation.
Related Articles Conformational Ensembles in GPCR Activation.
Cell. 2013 Jan 31;152(3):385-6
Authors: Vardy E, Roth BL
Abstract
Recent advances in G-protein-coupled receptor structural biology have provided only limited insight into the active conformations of these key signaling molecules. A paper from Nygaard et*al. reveals the dynamic nature of GPCRs along the activation pathway by complementing NMR experiments with ultralong-timescale molecular dynamics simulations.
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02-05-2013 09:51 PM
[NMR paper] Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography.
Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography.
Related Articles Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography.
EMBO J. 2004 Apr 21;23(8):1699-708
Authors: Häussinger D, Ahrens T, Aberle T, Engel J, Stetefeld J, Grzesiek S
Cellular adhesion by classical cadherins depends critically on the exact proteolytic removal of their N-terminal prosequences. In this combined solution NMR and X-ray crystallographic study, the consequences of propeptide cleavage of an epithelial...
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11-24-2010 09:51 PM
[NMR paper] Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated co
Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc-MS.gif Related Articles Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering.
J Biol Chem. 1993 Jun 25;268(18):13081-8
Authors: Drake SK, Bourret RB, Luck LA, Simon MI, Falke JJ
CheY, the 14-kDa response regulator protein of...
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08-21-2010 11:53 PM
[NMR paper] 19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by
19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-.
Related Articles 19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-.
J Biol Chem. 1991 Feb 25;266(6):3396-401
Authors: Higashijima T, Graziano MP, Suga H, Kainosho M, Gilman AG
19F and 31P NMR spectroscopy was used to study the mechanism of activation of the alpha subunits of guanine nucleotide-binding regulatory proteins (G proteins) by Al3+, Mg2+, and F-. 19F NMR spectra of solutions containing Al3+,...
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08-21-2010 11:16 PM
[NMR paper] NMR studies of the activation of the Escherichia coli trp repressor.
NMR studies of the activation of the Escherichia coli trp repressor.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_FREE_120x27.gif Related Articles NMR studies of the activation of the Escherichia coli trp repressor.
Eur J Biochem. 1991 Nov 1;201(3):569-79
Authors: Hyde EI, Ramesh V, Frederick R, Roberts GC
The Escherichia coli trp repressor binds to the trp operator in the presence of tryptophan, thereby inhibiting tryptophan biosynthesis. Tryptophan analogues...
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08-21-2010 11:12 PM
[NMR paper] NMR studies of the activation of the Escherichia coli trp repressor.
NMR studies of the activation of the Escherichia coli trp repressor.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_pubmed_logo_FREE_120x27.gif Related Articles NMR studies of the activation of the Escherichia coli trp repressor.
Eur J Biochem. 1991 Nov 1;201(3):569-79
Authors: Hyde EI, Ramesh V, Frederick R, Roberts GC
The Escherichia coli trp repressor binds to the trp operator in the presence of tryptophan, thereby inhibiting tryptophan biosynthesis. Tryptophan analogues...