Characterization of the Functional Variance in MbtH-likeProtein Interactions with a Nonribosomal Peptide Synthetase
Characterization of the Functional Variance in MbtH-likeProtein Interactions with a Nonribosomal Peptide Synthetase
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00517/20170920/images/medium/bi-2017-00517a_0009.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00517
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nmrlearner
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09-21-2017 02:38 AM
[NMR paper] Peptide-Directed Binding for the Discovery of Modulators of ?-Helix-Mediated Protein–Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1
Peptide-Directed Binding for the Discovery of Modulators of ?-Helix-Mediated Protein–Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1
Targeting PPIs with small molecules can be challenging owing to large, hydrophobic binding surfaces. Herein, we describe a strategy that exploits selective ?-helical PPIs, transferring these characteristics to small molecules. The proof of concept is demonstrated with the apoptosis regulator Mcl-1, commonly exploited by cancers to avoid cell death. Peptide-directed binding uses few synthetic transformations, requires the...
nmrlearner
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07-25-2017 07:46 PM
[NMR paper] Peptide directed binding; a novel approach for the discovery of modulators of alpha-helix mediated protein-protein interactions demonstrated with apoptosis regulating Mcl-1
Peptide directed binding; a novel approach for the discovery of modulators of alpha-helix mediated protein-protein interactions demonstrated with apoptosis regulating Mcl-1
Targeting PPIs with small molecules can be challenging due to large, hydrophobic binding surfaces. Here, we describe a strategy that exploits selective alpha-helical PPIs, transferring these characteristics to small molecules. The proof-of-concept is exemplified with the apoptosis regulator Mcl-1, commonly exploited by cancers to avoid cell death. Peptide directed binding uses few synthetic transformations, requires...
nmrlearner
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07-03-2017 02:31 AM
Acyl Carrier Protein Cyanylation Delivers a KetoacylSynthase–Carrier Protein Cross-Link
Acyl Carrier Protein Cyanylation Delivers a KetoacylSynthase–Carrier Protein Cross-Link
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00219/20170508/images/medium/bi-2017-00219v_0003.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00219
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nmrlearner
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05-09-2017 12:37 AM
[NMR paper] Structural and Biochemical Analysis of Protein–Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain
Structural and Biochemical Analysis of Protein–Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain
In fungal non-reducing polyketide synthases (NR-PKS) the acyl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elongation, cyclization and product release. This process occurs through a controlled, yet enigmatic coordination of the ACP with its partner enzymes. The transient nature of ACP interactions with these catalytic domains imposes a major obstacle for investigation of the influence of protein–protein...
nmrlearner
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09-22-2016 10:41 PM
Substrate–Protein Interactions of Type II NADH:QuinoneOxidoreductase from Escherichia coli
Substrate–Protein Interactions of Type II NADH:QuinoneOxidoreductase from Escherichia coli
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.6b00070/20160505/images/medium/bi-2016-00070d_0011.gif
Biochemistry
DOI: 10.1021/acs.biochem.6b00070
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nmrlearner
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05-06-2016 03:39 AM
[NMR paper] NMR Identification of the Binding Surfaces Involved in the Salmonella and Shigella Type III Secretion Tip-Translocon Protein-Protein Interactions.
NMR Identification of the Binding Surfaces Involved in the Salmonella and Shigella Type III Secretion Tip-Translocon Protein-Protein Interactions.
Related Articles NMR Identification of the Binding Surfaces Involved in the Salmonella and Shigella Type III Secretion Tip-Translocon Protein-Protein Interactions.
Proteins. 2016 Apr 19;
Authors: McShan AC, Kaur K, Chatterjee S, Knight KM, De Guzman RN
Abstract
The type III secretion system (T3SS) is essential for the pathogenesis of many bacteria including Salmonella and Shigella,...
nmrlearner
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04-20-2016 05:09 PM
Transferred NOESY NMR studies of biotin mimetic peptide (FSHPQNT) bound to streptavidin: A structural model for studies of peptide-protein interactions.
Transferred NOESY NMR studies of biotin mimetic peptide (FSHPQNT) bound to streptavidin: A structural model for studies of peptide-protein interactions.
Transferred NOESY NMR studies of biotin mimetic peptide (FSHPQNT) bound to streptavidin: A structural model for studies of peptide-protein interactions.
Chem Biol Drug Des. 2011 Feb 5;
Authors: Gizachew D, Dratz E
Protein-protein interactions control signaling, specific adhesion and many other biological functions. The three dimensional structures of the interfaces and bound ligand can be...
Manipulating Protein–Protein Interactions inNonribosomal Peptide Synthetase Type II Peptidyl Carrier Proteins
Linear Mode
