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Old 09-12-2011, 09:00 PM
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Default Low-field one-dimensional and direction-dependent relaxation imaging of bovine articular cartilage

Low-field one-dimensional and direction-dependent relaxation imaging of bovine articular cartilage


Publication year: 2011
Source: Journal of Magnetic Resonance, Available online 10 September 2011

Erik*Rössler, Carlos*Mattea, Ayret*Mollova, Siegfried*Stapf

The structure of articular cartilage is separated into three layers of differently oriented collagen fibers, which is accompanied by a gradient of increasing glycosaminoglycan (GAG) and decreasing water concentration from the top layer towards the bone interface. The combined effect of these structural variations results in a change of the longitudinal and transverse relaxation times as a function of the distance from the cartilage surface. In this paper, this dependence is investigated at a magnetic field strength of 0.27 T with a one-dimensional depth resolution of 50 ?m on bovine hip and stifle joint articular cartilage. By employing this method, advantage is taken of the increasing contrast of the longitudinal relaxation rate found at lower magnetic field strengths. Furthermore, evidence for an orientational dependence of relaxation times with respect to an axis normal to the surface plane is given, an observation that has recently been reported using high-field MRI and that was explained by preferential orientations of collagen bundles in each of the three cartilage zones. In order to quantify the extent of a further contrast mechanism and to estimate spatially dependent glycosaminoglycan concentrations, the data are supplemented by proton relaxation times that were acquired in bovine articular cartilage that was soaked in a 0.8mM aqueous Gdsolution.

Graphical abstract



Highlights

? Bovine articular cartilage was investigated by low-field 1D MRI at 50 ?m resolution. ? Relaxation times T1, T2 reveal internal cartilage structure. ? Strong T1 variations are found, in contrast to high-field studies. ? Contrast agents allow the estimation of local GAG (protein) concentrations. ? Angular dependence of T2 indicates preferred collagen fiber orientation.



Source: Journal of Magnetic Resonance
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