Related ArticlesLEGO-NMR Spectroscopy: A Method to Visualize Individual Subunits in Large Heteromeric Complexes.
Angew Chem Int Ed Engl. 2013 Aug 14;
Authors: Mund M, Overbeck JH, Ullmann J, Sprangers R
Abstract
Seeing the big picture: Asymmetric macromolecular complexes that are NMR active in only a subset of their subunits can be prepared, thus decreasing NMR spectral complexity. For the hetero heptameric LSm1-7 and LSm2-8 rings NMR spectra of the individual subunits of the complete complex are obtained, showing a conserved RNA binding site. This LEGO-NMR technique makes large asymmetric complexes accessible to detailed NMR spectroscopic studies.
PMID: 23946163 [PubMed - as supplied by publisher]
New solid state NMR method can help visualize structure of proteins - News-Medical.net
New solid state NMR method can help visualize structure of proteins - News-Medical.net
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New solid state NMR method can help visualize structure of proteins
News-Medical.net
For roughly a decade, a technique called solid state nuclear magnetic resonance (NMR) spectroscopy has allowed researchers to detect the arrangements of atoms in proteins that defy study by traditional laboratory tools such as X-ray crystallography.
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Solid-State (17)O NMR Spectroscopy of Large Protein-Ligand Complexes.
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Angew Chem Int Ed Engl. 2010 Jul 28;
Authors: Zhu J, Ye E, Terskikh V, Wu G
LEGO-NMR Spectroscopy: A Method to Visualize Individual Subunits in Large Heteromeric Complexes.
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