Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR.
Chem Commun (Camb). 2018 Mar 21;:
Authors: Ward ME, Daniëls MA, van Kappel EC, Maurice MM, Baldus M
Abstract
We report solid-state Nuclear Magnetic Resonance (ssNMR) studies on amyloid-like protein complexes formed by DIX domains that mediate key protein interactions in the Wnt signalling pathway. Our results provide insight into the 3D fold of the self-associated Axin-DIX domain and identify a potential lipid cofactor.
PMID: 29561051 [PubMed - as supplied by publisher]
Surface Binding of TOTAPOL Assists Structural Investigations of Amyloid Fibrils by Dynamic Nuclear Polarization NMR Spectroscopy #DNPNMR
From The DNP-NMR Blog:
Surface Binding of TOTAPOL Assists Structural Investigations of Amyloid Fibrils by Dynamic Nuclear Polarization NMR Spectroscopy #DNPNMR
p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Nagaraj, M., et al., Surface Binding of TOTAPOL Assists Structural Investigations of Amyloid Fibrils by Dynamic Nuclear Polarization NMR Spectroscopy. Chembiochem, 2016. 17(14): p. 1308-11.
https://www.ncbi.nlm.nih.gov/pubmed/27147408
nmrlearner
News from NMR blogs
0
07-06-2017 01:51 AM
[NMR paper] Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.
Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.
Related Articles Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy.
Biochim Biophys Acta. 2017 Jun 06;:
Authors: Naito A, Matsumori N, Ramamoorthy A
Abstract
A variety of biomolecules acting on the cell membrane folds into a biologically active structure in the membrane environment. It is, therefore,...
nmrlearner
Journal club
0
06-11-2017 06:00 PM
Surface Binding of TOTAPOL Assists Structural Investigations of Amyloid Fibrils by Dynamic Nuclear Polarization NMR Spectroscopy #DNPNMR
From The DNP-NMR Blog:
Surface Binding of TOTAPOL Assists Structural Investigations of Amyloid Fibrils by Dynamic Nuclear Polarization NMR Spectroscopy #DNPNMR
p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Nagaraj, M., et al., Surface Binding of TOTAPOL Assists Structural Investigations of Amyloid Fibrils by Dynamic Nuclear Polarization NMR Spectroscopy. Chembiochem, 2016. 17(14): p. 1308-11.
https://www.ncbi.nlm.nih.gov/pubmed/27147408
nmrlearner
News from NMR blogs
0
12-28-2016 04:14 PM
[NMR paper] Solid-State NMR Studies Reveal Native-like ?-sheet Structures in Transthyretin amyloid.
Solid-State NMR Studies Reveal Native-like ?-sheet Structures in Transthyretin amyloid.
Related Articles Solid-State NMR Studies Reveal Native-like ?-sheet Structures in Transthyretin amyloid.
Biochemistry. 2016 Sep 2;
Authors: Lim KH, Dasari AK, Hung IF, Gan Z, Kelly JW, Wright PE, Wemmer DE
Abstract
Structural characterization of amyloid rich in cross-? structures is crucial for unraveling molecular basis of protein misfolding and amyloid formation associated with a wide range of human disorders. Elucidation of the ?-sheet...
[NMR paper] Structural Investigations of Molecular Machines by Solid-State NMR.
Structural Investigations of Molecular Machines by Solid-State NMR.
Related Articles Structural Investigations of Molecular Machines by Solid-State NMR.
Acc Chem Res. 2013 Mar 15;
Authors: Loquet A, Habenstein B, Lange A
Abstract
Essential biological processes such as cell motion, signaling,protein synthesis, and pathogen-host interactions rely on multifunctional molecular machines containing supramolecular assemblies, that is, noncovalently assembled protein subunits. Scientists would like to acquire a detailed atomic view of the complete...
nmrlearner
Journal club
0
03-19-2013 01:22 PM
Preparation of RNA samples with narrow line widths for solid state NMR investigations
Preparation of RNA samples with narrow line widths for solid state NMR investigations
Publication year: 2012
Source:Journal of Magnetic Resonance</br>
Wei Huang, Michael F. Bardaro, Gabriele Varani, Gary P. Drobny</br>
Solid state NMR can provide detailed structural and dynamic information on biological systems that cannot be studied under solution conditions, and can investigate motions which occur with rates that cannot be fully studied by solution NMR. This approach has successfully been used to study proteins, but the application of multidimensional solid state...
nmrlearner
Journal club
0
08-10-2012 08:40 PM
NMR-Spectroscopic and Solid-State Investigations of Cometal-Free Asymmetric Conjugate
NMR-Spectroscopic and Solid-State Investigations of Cometal-Free Asymmetric Conjugate Addition: A Dinuclear Paracyclophaneimine Zinc Methyl Complex
S. Ay et al
http://pubs.acs.org//appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja1032502/aop/images/medium/ja-2010-032502_0003.gifJournal of the American Chemical Society, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable).
Source: Journal of the American Chemical Society
Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR.
Linear Mode
