Related ArticlesInvestigating protein conformational energy landscapes and atomic resolution dynamics from NMR dipolar couplings: a review.
Rep Prog Phys. 2015 Oct 30;78(12):126601
Authors: Salmon L, Blackledge M
Abstract
Nuclear magnetic resonance spectroscopy is exquisitely sensitive to protein dynamics. In particular inter-nuclear dipolar couplings, that become measurable in solution when the protein is dissolved in a dilute liquid crystalline solution, report on all conformations sampled up to millisecond timescales. As such they provide the opportunity to describe the Boltzmann distribution present in solution at atomic resolution, and thereby to map the conformational energy landscape in unprecedented detail. The development of analytical methods and approaches based on numerical simulation and their application to numerous biologically important systems is presented.
PMID: 26517337 [PubMed - as supplied by publisher]
Modulating RNA Alignment Using Directional Dynamic Kinks: Application in Determining an Atomic-Resolution Ensemble for a Hairpin using NMR Residual Dipolar Couplings
Modulating RNA Alignment Using Directional Dynamic Kinks: Application in Determining an Atomic-Resolution Ensemble for a Hairpin using NMR Residual Dipolar Couplings
Loi?c Salmon, George M. Giambas?u, Evgenia N. Nikolova, Katja Petzold, Akash Bhattacharya, David A. Case and Hashim M. Al-Hashimi
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.5b07229/20150929/images/medium/ja-2015-07229f_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.5b07229
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA ...
[NMR paper] Mapping the population of protein conformational energy sub-States from NMR dipolar couplings.
From Mendeley Biomolecular NMR group:
Mapping the population of protein conformational energy sub-States from NMR dipolar couplings.
Angewandte Chemie (International ed. in English) (2013). Volume: 52, Issue: 11. Pages: 3181-5. Paul Guerry, Loïc Salmon, Luca Mollica, Jose-Luis Ortega Roldan, Phineus Markwick, Nico a J van Nuland, J Andrew McCammon, Martin Blackledge et al.
Molecular dynamics: A general method for the statistical mechanical description of conformational energy landscapes of proteins in solution is proposed. This method combines NMR residual dipolar couplings (RDCs),...
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10-17-2013 12:49 PM
[NMR paper] Mapping Protein Conformational Energy Landscapes Using NMR and Molecular Simulation.
Mapping Protein Conformational Energy Landscapes Using NMR and Molecular Simulation.
Mapping Protein Conformational Energy Landscapes Using NMR and Molecular Simulation.
Chemphyschem. 2013 May 23;
Authors: Guerry P, Mollica L, Blackledge M
Abstract
Nuclear magnetic resonance (NMR) spectroscopy provides detailed understanding of the nature and extent of protein dynamics on physiologically important timescales. We present recent advances in the combination of NMR with state-of-the-art molecular simulation that are providing unique new...
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05-25-2013 12:05 PM
[NMR paper] Mapping the population of protein conformational energy sub-States from NMR dipolar couplings.
From Mendeley Biomolecular NMR group:
Mapping the population of protein conformational energy sub-States from NMR dipolar couplings.
Angewandte Chemie (International ed. in English) (2013). Volume: 52, Issue: 11. Pages: 3181-5. Paul Guerry, Loïc Salmon, Luca Mollica, Jose-Luis Ortega Roldan, Phineus Markwick, Nico a J van Nuland, J Andrew McCammon, Martin Blackledge et al.
Molecular dynamics: A general method for the statistical mechanical description of conformational energy landscapes of proteins in solution is proposed. This method combines NMR residual dipolar couplings (RDCs),...
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04-11-2013 03:08 PM
A General Method for Constructing Atomic-ResolutionRNA Ensembles using NMR Residual Dipolar Couplings: The Basis forInterhelical Motions Revealed
A General Method for Constructing Atomic-ResolutionRNA Ensembles using NMR Residual Dipolar Couplings: The Basis forInterhelical Motions Revealed
Loi?c Salmon, Gavin Bascom, Ioan Andricioaei and Hashim M. Al-Hashimi
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja400920w/aop/images/medium/ja-2013-00920w_0006.gif
Journal of the American Chemical Society
DOI: 10.1021/ja400920w
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/hvS4n8AO9ys
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03-29-2013 07:07 AM
[NMR paper] A General Method for Constructing Atomic-Resolution RNA Ensembles using NMR Residual Dipolar Couplings: The Basis for Inter-helical Motions Revealed.
A General Method for Constructing Atomic-Resolution RNA Ensembles using NMR Residual Dipolar Couplings: The Basis for Inter-helical Motions Revealed.
Related Articles A General Method for Constructing Atomic-Resolution RNA Ensembles using NMR Residual Dipolar Couplings: The Basis for Inter-helical Motions Revealed.
J Am Chem Soc. 2013 Mar 8;
Authors: Salmon L, Bascom GD, Andricioaei I, Al-Hashimi HM
Abstract
The ability to modulate alignment and measure multiple independent sets of NMR residual dipolar couplings (RDCs) has made it possible...
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03-12-2013 07:09 PM
[NMR paper] Mapping the Population of Protein Conformational Energy Sub-States from NMR Dipolar Couplings.
Mapping the Population of Protein Conformational Energy Sub-States from NMR Dipolar Couplings.
Related Articles Mapping the Population of Protein Conformational Energy Sub-States from NMR Dipolar Couplings.
Angew Chem Int Ed Engl. 2013 Feb 1;
Authors: Guerry P, Salmon L, Mollica L, Ortega Roldan JL, Markwick P, van Nuland NA, McCammon JA, Blackledge M
Abstract
Molecular dynamics: A general method for the statistical mechanical description of conformational energy landscapes of proteins in solution is proposed. This method combines NMR...
Investigating protein conformational energy landscapes and atomic resolution dynamics from NMR dipolar couplings: a review.
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